The objective is to assess the effectiveness of a multicomponent program of active aging in the improvement of the functional physical condition of patients older than 65years old with social risk.

Pragmatic clinical trial non-blinded.

Community activity; primary care and public education center.

Patients older than 65years and diagnosed with social risk. The patients who attended at the health center and fulfilled the inclusion criteria were selected consecutively (n=102).

The patients were randomized into the intervention group or to the control group. The intervention included two weekly sessions of 1h of exercise during 4months, monthly health education sessions, and three days of social activities. check details The control group received the regular tips. The physical conditions were evaluated before and at the end the study.

Eighty of the patients completed the study. Their middle age was 71.5±5 years old, and 91.3% of them were women. There was no significant differences between both groups. After the intervention, all the test for physical qualities improved in the intervention group; in the 6-minutes walk test the patients improved their mark in a 98% from the baseline marks, with an average increase of 65±35m. Flexibility improved in the 60% of the patients (95%CI 50-70); strength increased an 84% (95%CI 76-92), and dynamic balance increased a 79% (95%CI 70-88). In control group improve some test marks but it had no statistical significance.

The socio-motor intervention program coordinated between health services and educational centers improves the functional physical condition of the elderly with social risk.

The socio-motor intervention program coordinated between health services and educational centers improves the functional physical condition of the elderly with social risk.

Pre-hypertension remains a significant public health challenge and appropriate intervention is required to stop its progression to hypertension and/or cardiovascular diseases.

To study the effects of individualized homeopathic medicines (IH) against placebo in intervening with the progression of pre-hypertension to hypertension.

Double-blind, randomized, two parallel arms, placebo-controlled trial.

Outpatient departments of D. N. De Homoeopathic Medical College and Hospital, Kolkata, West Bengal, India.

Ninety-two patients suffering from pre-hypertension; randomized to receive either IH (n=46) or identical-looking placebo (n=46).

IH or placebo in the mutual context of lifestyle modification (LSM) advices including dietary approaches to stop hypertension (DASH) and brisk exercises.

Primary – systolic and diastolic blood pressure (SBP and DBP); secondary – Measure Yourself Medical Outcome Profile version 2.0 (MYMOP-2) scores; all measured at baseline, and every month, up to 3 months.

After 3 monpathy, which ultimately rendered the trial as inconclusive. [Trial registration CTRI/2018/10/016,026; UTN U1111-1221-8251].This study reviews observational studies regarding alleged past-life memories published as scientific articles, and points out their bibliometric and methodological characteristics. Scientific databases were screened (Scopus, Web of Science, PubMed/Medline, PsycINFO, Scielo, and OpenGrey). The 78 included studies were classified by their methodological and bibliometric characteristics. The peak of publications occurred from 1990 to 2010 (45%), and Asia was the most investigated territory (58 studies); most of investigations were related to children (84%) and case report was the predominant study design (60%). Interview was the predominant methodological approach (73%), followed by documental analysis (50%). Claimed past-life memories (100%), unusual behaviors (74%) and birthmarks/defects (37%) were the most investigated variables. Investigations of past-life memories should be encouraged around all cultures, and future studies should consider previous methodological features and try to overcome their limitations.

assess if mediums could give accurate information about the deceased in a triple-blind protocol and to investigate the source of information using a quantitative and qualitative analysis.

nine mediums produced thirty-eight readings related to thirty-eight deceased individuals chosen by thirty-six sitters using a triple-blind protocol with no direct interaction with the sitters themselves. In this protocol, the medium was provided with only the deceased’s name by the interviewer, the latter having no further knowledge about the deceased. link2 In every session, the medium was asked to provide information about two deceased persons of the same gender. This information, excluding generic details, was entered into two anonymous lists. The information of these two readings was sent to the research assistant charged with maintaining contact with the sitters. Each sitter was asked to assign a value to every piece of information listed using a four- point Likert scale from ‘totally wrong’ to ‘totally correct’, and to provide a global score for each reading.

65.8% of the intended readings were correctly identified with respect to the chance of 50%. Furthermore, intended readings had on average 29.5% more correct information than the control ones. Qualitative data indicate that mediums attain information both passively and actively, that is as if they retrieved information without or directly interacting with the deceased.

this study provides further evidence that some mediums are able to obtain accurate information about deceased people knowing only the deceased’s name and with no interaction with sitters; it also supports the hypothesis that, in some cases, the sources of the information are the deceased themselves.

this study provides further evidence that some mediums are able to obtain accurate information about deceased people knowing only the deceased’s name and with no interaction with sitters; it also supports the hypothesis that, in some cases, the sources of the information are the deceased themselves.

To focus on technical aspects of the implementation of interstitial high dose rate brachytherapy, with a step-by-step approach.

Patients were selected during multidisciplinary tumor boards, according to inclusion criteria adapted from GEC-ESTRO guidelines. A CT scan was performed a few days before implantation. On pre-implant CT, using surgical scar and clips, surgical and pathological reports, and preoperative images, we delineated the tumor bed to be included in the Clinical Target Volume (CTV), according to GEC ESTRO Recommendations. A 3D virtual implant simulation of the best catheter positions was performed in order to cover the target volume. link3 Implantation was then carried out under local anaesthetic using 3D projections of the catheter inlets and outlets. Dosimetry was performed on post-implantation CT scan. A dose of 34Gy was delivered in 10 fractions. Acute and late side effects, and local control were evaluated 2 and 8 months after treatment.

Between July 2017 and January 2020, 20 patients were treated with accelerated partial breast irradiation. Dose constraints regarding target volume coverage, overdose, dose homogeneity, conformation index and organs at risk were met in 94.7%, 100%, 63.2%, 0% and 89.5% of the treatment plans, respectively. Grade 1-2 acute adverse events were observed in 21% of patients, with no grade 3-4 events.

The first dosimetric results and early clinical tolerance and efficacy achieved by the implementation of breast interstitial multicatheter brachytherapy in routine clinical practice are very encouraging, and confirm the interest of extending this practice.

The first dosimetric results and early clinical tolerance and efficacy achieved by the implementation of breast interstitial multicatheter brachytherapy in routine clinical practice are very encouraging, and confirm the interest of extending this practice.

Annona reticulata L. is a traditionally important plant due to its versatile source of medicine and industrial products. It is used to treat cardiac problems, wound healing, diabetes, ulcers and bacterial infections. As it is a commercial fruit bearing plant, wide range studies on this plant reaches the mankind efficiently.

The present study was focussed on antihyperglycemic potential of A.reticulata leaves under invitro and invivo.

The invitro phytochemical analysis, total phenolic, flavonoid content, inhibition activity on alpha amylase and alpha glucosidase enzymes were determined for various solvent extracts, followed by invivo oral toxicity, short term, dose dependant antihyperglycemic studies, oral glucose tolerance tests were performed. The activity of methanolic extract of A.reticulata (MeEAR)-500mg/kg b.wt was studied for 28 days in diabetic rat model. Histopathological examinations and serum biochemical assays were performed. Gas chromatography-Mass spectrometry (GC-MS) analysis was performed to identify the compounds present in MeEAR.

Among the various extracts, MeEAR possesses higher amount of phenols and flavonoids with effective inhibition on carbohydrate hydrolysing enzymes (P<0.05) and also exhibited higher glycemic control invivo, with simultaneous improvement in the hepatic and renal activities in diabetic rats. GC-MS analysis revealed the presence of 63 bioactive compounds including carboxylic-acids, alcoholic groups, fattyacid esters, amino acid derivatives.

Altogether, our study demonstrated that leaves of A.reticulata possess better antihyperglycemic activity and could be developed in to a potential antidiabetic drug with further studies.

Altogether, our study demonstrated that leaves of A.reticulata possess better antihyperglycemic activity and could be developed in to a potential antidiabetic drug with further studies.Research using avian embryos has led to major conceptual advances in developmental biology, virology, immunology, genetics and cell biology. The avian embryo has several significant advantages, including ready availability and ease of accessibility, rapid development with marked similarities to mammals and a high amenability to manipulation. As mechanical forces are increasingly recognised as key drivers of morphogenesis, this powerful model system is shedding new light on the mechanobiology of embryonic development. Here, we highlight progress in understanding how mechanical forces direct key morphogenetic processes in the early avian embryo. Recent advances in quantitative live imaging and modelling are elaborating upon traditional work using physical models and embryo manipulations to reveal cell dynamics and tissue forces in ever greater detail. The recent application of transgenic technologies further increases the strength of the avian model and is providing important insights about previously intractable developmental processes.To curtail the rising tide of antiscience threatening the health and progress of society, scientists are increasingly engaging with the public. Here, we describe our approach to write accessible books based on personal stories as a means to help spread scientific literacy to those who normally do not read science.Small RNAs are crucial for the regulation of basic cellular processes and protection against viruses and transposons in mosquitoes. Rozen-Gagnon et al. established CLIP (cross-linking and immunoprecipitation) for Argonaute proteins in Aedes aegypti. Their study sheds light on small RNA-target interactions in mosquitoes and provides an important resource for further study.