The coccidian genus Eumonospora Allen, 1933 is re-established. Despite morphological features and host preference among species, coccidian with octasporozoic and monosporocystic oocysts are traditionally consider to belonging in the genus Caryospora Léger, 1904 (Apicomplexa Eimeriidae). buy Sodium L-lactate Recently, the genus Avispora Chuster et al., 2016 was proposed for above caryosporoids parasitizing birds based on combined morphological and phylogenetic analyses. However, diagnostic morphological characters of the genus Avispora, the absence of Stieda and substieda bodies, has already been mentioned in the description of the genus Eumonospora Allen, 1933 (Apicomplexa Sarcocystidae), and thus Avispora is considered to be a junior synonym of Eumonospora. In this study, caryosporoid coccidians were detected from five owl species; Bubo scandiacus, Ptilopsis leucotis, Athene noctua, Strix nebulosa, and Pulsatrix perspicillata (Strigiformes Strigidae) and identified as Avispora henryae (Yakimoff & Matikaschwaili, 1932) described from Bubo bubo (Strigiformes Strigidae). Eumonospora henryae (Yakimoff & Matikaschwili, 1932) comb. nov. is redescribed for this species based not only on morphological features but also on phylogenetical analyses. The key of the genus Eumonospora and a list to the species known at present are also provided. V.Non-invasive diagnostic strategies, such as optical coherence tomography (OCT) enable detailed examination of skin tissue architecture and have potential for identification and subtyping of BCC. The group of cutaneous CD30-positive lymphoproliferative disorders (LPD) comprises two different entities, namely lymphomatoid papulosis (LyP) and cutaneous anaplastic large T-cell lymphoma (cALCL). LyP constitutes a benign lymphoproliferation with spontaneously regressing papules, whereas cALCL presents with solitary or multiple skin tumors with a low propensity to disseminate. To elucidate the hitherto largely unknown molecular pathogenesis of these entities, we performed comprehensive next generation sequencing in a well-characterized cohort of 12 patients. Considering the low tumor cell content of LyP, we applied targeted sequencing technologies with a hybrid capture-based DNA library preparation approach and for the identification of fusion transcripts an anchored multiplex PCR enrichment kit. As the major finding, we detected in 50% of LPD genetic events that imply a constitutively activated JAK-STAT pathway in these entities. The identified molecular aberrations comprised either pathogenic STAT mutations or oncogenic fusion transcripts comprising effector domains of JAK. With respect to LyP, we demonstrate to our knowledge such previously unreported genetic aberrations in this specific entity. The detection of these convergent aberrations within the JAK-STAT signaling pathway deciphers common potential driving mechanisms of lymphomagenesis within LPD being shared between LyP and cALCL. Moreover, the presence of these oncogenic alterations paves the way to develop novel personalized treatment strategies. OBJECTIVES Alexithymia is a personality construct that could occur in up to 53 % of patients with multiple sclerosis (MS). It entails difficulties in identifying and describing one’s feelings and an externally oriented thinking. The current work aims to assess the neural underpinnings of alexithymia in this population. METHODS Forty-five patients with MS filled in the Toronto Alexithymia Scale (n = 17 with high alexithymia and n = 28 with low alexithymia). Brain magnetic resonance imaging was obtained for each patient and a morphometry algorithm (MorphoBox) was applied to calculate regional brain volumes. All patients underwent a clinical and neuropsychological evaluation which included measures for anxiety, depression, fatigue, daytime sleepiness, and basic and social cognition. RESULTS Compared to patients with low alexithymia, patients with high alexithymia had significantly higher fatigue and depression ratings, and lower empathy scores. In addition, they had lower volumes of corpus callosum, deep white matter, pallidum bilaterally, and left thalamus. In the whole cohort, alexithymia scores were inversely correlated with gray matter (thalamus and pallidum bilaterally) and white matter volumes (corpus callosum and bilateral deep white matter) after controlling for covariates (ps less then 0.05). CONCLUSION This study offers insights on the neuropsychological and neural substrates of alexithymia in MS. The current findings are consistent with alexithymia reports in other clinical populations, and suggest an association between alexithymia and atrophy of thalami, pallidum, corpus callosum and deep white matter in MS. Further research is needed to enhance the understanding of alexithymia mechanisms in this clinical context. Interval timing measures time estimation in the seconds-to-minutes range. Antarctica provides a real-world context to study the effect of extreme photoperiods and isolation on time perception. The aim of this study was to explore interval timing as a cognitive measure in the crew of Belgrano II Argentine Antarctic Station. A total of 13 subjects were assessed for interval timing in short (3 s), intermediate (6 s) and long (12 s) duration stimuli. Measures were taken during the morning and evening, five times along the year. Significant variations were found for 3 s and 6 s during the morning and 6 s during the evening. Results suggest an impact of isolation on morning performances and an effect of the polar night on evening measures. These findings shed some light on the use of interval timing as a cognitive test to assess performance in extreme environments. The Heat Shock Factors (HSFs) have been historically identified as a family of transcription factors that are activated and work in a stress-responsive manner, after exposure to a large variety of stimuli. However, they are also critical in normal conditions, in a life long manner, in a number of physiological processes that encompass gametogenesis, embryonic development and the integrity of adult organs and organisms. The importance of such roles is emphasized by the devastating impact of their deregulation on health, ranging from reproductive failure, neurodevelopmental disorders, cancer, and aging pathologies, including neurodegenerative disorders. Here, we provide an overview of the delicate choreography of the regulation of HSFs during neurodevelopment, at prenatal and postnatal stages. The regulation of HSFs acts at multiple layers and steps, and comprises the control of (i) HSF mRNA and protein levels, (ii) HSF activity in terms of DNA-binding and transcription, (iii) HSF homo- and hetero-oligomerization capacities, and (iv) HSF combinatory set of post-translational modifications.