PURPOSE The effects of exercise-based cardiac rehabilitation (CR) on parasympathetic modulation are controversial. This systematic review and meta-analysis aims to (a) determine the effect of exercise-based CR on heart-rate-derived indices associated with cardiac parasympathetic modulation in resting and post-exercise conditions in coronary artery disease (CAD) patients and (b) identify the possible moderator variables of the effect of exercise-based CR on parasympathetic modulation. METHODS We searched CENTRAL and Web of Science up to November 2018 for the following terms adult CAD patients, controlled exercise-based CR interventions and parasympathetic modulation measured in resting (vagal-related heart rate variability [HRV] indices of the root mean square of the differences in successive in RR interval [RMSSD] and high frequency [HF]) and post-exercise (heart rate recovery [HRR]) pre- and post-intervention. We estimated a random-effects model of standardised mean difference (SMD) and mean difference (MD) controversial due to methodological inconsistencies in measuring HRV, with the use of RMSSD recommended instead of HF because its results show higher consistency. Future studies involving women, focusing on methodological issues, and performing other training methods are needed to increase our knowledge about this topic.Biorepositories have been established and used for the collection, storage, and distribution of biological materials for research and improving health. selleck inhibitor The terms “biobank” and “biorepository” are often used interchangeably, and they have been employed for more than a century to maintain and reallocate the biospecimens. The biorepository begins with the aim of data collection and the expected future use of human biological materials/specimens. Biorepository on cancer, diabetes, infectious disease, neurological disorders, syndromes are established but they are located in the developed world. To make it a universally accessible virtual global repository is required. A virtual biobank is an electronic database of biological specimens and other related information that exists effectively, independent of where the actual specimens are stored. Virtual biorepositories could be consortia of national or international repositories, that can provide source material and data to researchers in any part of the world which is urgently needed and highly meaningful for result-oriented research in global health care.Multitasking on digital devices during social interactions has become increasingly common, but research on this behavior is far from thorough. Expanding on literature of phubbing and technoference, the authors proposed a theoretical framework, digital social multitasking, defined as performing technology-based multitasking during a social interaction, to study the behavior. This mixed-methods study focused on one type of digital social multitasking phone use during a face-to-face interaction with a friend. Self-report survey data were collected from 222 college students (Mage = 19.87; 82% female; 45% Black or African American, 43% White or European American). Results showed that digital social multitasking mostly took place when the face-to-face interaction was casual, and the majority of the phone-based activities were shared between the participant and the friend. Participants did not hold a negative view of their own or friend’s digital social multitasking, but when they saw their own multitasking as distracting or friend’s multitasking as dismissive, they reported lower friendship quality and higher loneliness. The level of one’s own and friend’s multitasking did not directly associate with friendship quality and loneliness; they only indirectly associated with the well-being outcomes via negative perception of the behavior. Friend’s digital social multitasking had stronger associations with poor socioemotional well-being when the face-to-face interactions were serious in nature. Overall, the socioemotional implications of college emerging adults’ phone use during peer interactions did not seem as alarming as what many may have believed, and the implications were contingent upon the context of the behavior.BACKGROUND Amid growing antimicrobial resistance, there is an increasing focus on antibiotic stewardship efforts to reduce inappropriate antibiotic prescribing. In this context, novel approaches for treating infections without antibiotics are being explored. One such strategy is the use of non-steroidal anti-inflammatory drugs (NSAIDs) for uncomplicated urinary tract infections (UTIs). Therefore, we conducted a systematic review of randomized controlled trials to evaluate the rates of symptom resolution and infectious complications in adult women with uncomplicated UTIs treated with antibiotics versus NSAIDs. METHODS We systematically searched PubMed, CINHAL, Scopus, Web of Science Core Collection, EMBASE, and ClinicalTrials.gov from inception until January 13, 2020, for randomized controlled trials comparing NSAIDs with antibiotics for treatment of uncomplicated UTIs in adult women. Studies comparing symptom resolution between groups were eligible. Two authors screened all studies independently and in duplicate; data were abstracted using a standardized template. Risk of bias was assessed using the Cochrane Collaboration tool. RESULTS Five randomized trials that included 1309 women with uncomplicated UTI met inclusion criteria. Three studies (1130 patients) favored antibiotic therapy in terms of symptom resolution. Two studies (179 patients) found no difference between NSAIDs and antibiotics in terms of symptom resolution. Three studies reported rates of pyelonephritis, two of which found higher rates in patients treated with NSAIDs versus antibiotics. Between two studies that reported this outcome (747 patients), patients randomized to NSAIDs received fewer antibiotic prescriptions compared with those in the antibiotics group. Three studies were at low risk of bias, one had an unclear risk of bias, and one was at high risk of bias. DISCUSSION For the outcomes of symptom resolution and complications in adult women with UTI, evidence favors antibiotics over NSAIDs. PROSPERO CRD42018114133.