Besides, the results of molecular docking showed that the main chemical components of HPTQ could be well combined with the targets of Bcl-2-associated X (Bax) and B-cell lymphoma2 (Bcl-2) and caspase-3. The levels of Bax/Bcl-2 protein ratio and caspase-3 increased in the DCD model while the HPTQ inhibited it. In addition, HPTQ restored DCD-induced decline of p-CREB, BDNF, TrkB, and p-Akt in the hippocampus.

These data indicated that HPTQ ameliorates the hippocampus apoptosis in diabetic cognitive dysfunction mice by activating CREB/BDNF/TrkB signaling pathway.

These data indicated that HPTQ ameliorates the hippocampus apoptosis in diabetic cognitive dysfunction mice by activating CREB/BDNF/TrkB signaling pathway.Traditional Chinese Medicine (TCM) clinical intelligent decision-making assistance has been a research hotspot in recent years. However, the recommendations of TCM disease diagnosis based on the current symptoms are difficult to achieve a good accuracy rate because of the ambiguity of the names of TCM diseases. The medical record data downloaded from ancient and modern medical records cloud platform developed by the Institute of Medical Information on TCM of the Chinese Academy of Chinese Medical Sciences (CACMC) and the practice guidelines data in the TCM clinical decision supporting system were utilized as the corpus. Based on the empirical analysis, a variety of improved Naïve Bayes algorithms are presented. The research findings show that the Naïve Bayes algorithm with main symptom weighted and equal probability has achieved better results, with an accuracy rate of 84.2%, which is 15.2% higher than the 69% of the classic Naïve Bayes algorithm (without prior probability). The performance of the Naïve Bayes classifier is greatly improved, and it has certain clinical practicability. The model is currently available at http//tcmcdsmvc.yiankb.com/.To investigate the effect and mechanism of action of Moriamin Forte (MF) on oligoasthenospermia (OA) in rats exposed to multiglycosides of Tripterygium wilfordii (GTW), forty male Sprague Dawley rats were randomly divided into four groups. Rats in the control group were treated with 0.5% sodium carboxymethyl cellulose. The remaining rats were administered GTW (30 mg/kg/d) for 40 d to establish an OA model. Concurrently, the groups were treated with normal saline and low-dose (100 mg/kg/d) and high-dose (200 mg/kg/d) MF, respectively. After treatment, the number and motility of sperm cells were examined. Testicular and epididymal histomorphology changes were observed. Antioxidant indicators (SOD, CAT, MDA, TAC, and Nrf2) in testicular and epididymal tissues were detected. Apoptotic and antiapoptotic indicators (Bax and Bcl2 expression) in the testicular tissue were measured by immunohistochemistry. GTW decreased sperm count and motility, damaged testicular and epididymis tissues, impaired antioxidase activity, and increased tissue MDA levels. Meanwhile, GTW upregulated the expression of Bax and downregulated the expression of Bcl2. Western blot analysis demonstrated a decrease in the Nrf2 expression in the model group. Adenosine disodium triphosphate Treatment with MF improved sperm count and motility, as well as inhibited the rate of apoptosis in the rat reproductive system. Moreover, MF improved the activity of antioxidants and increased the relative expression of the antioxidant pathway-related protein Nrf2. In conclusion, MF may reverse the GTW-induced OA by modulating the expression of apoptotic and antioxidant pathway-related proteins. This study may provide a pharmacological foundation for the use of MF in OA treatment.

Globally, work-related musculoskeletal disorders (WMSDs) have resulted in occupational disability and injury. Of these, restaurant workers are among the high-risk professionals usually affected by WMSDs. In Ethiopia, evidence on the burden of musculoskeletal disorder and contributing factors among restaurant workers were very limited. Therefore, this study was aimed at assessing the prevalence of self-reported WMSDs and contributing factors among restaurant workers in Gondar city, northwest Ethiopia, 2020.

An institutional-based cross-sectional study was conducted from February 2020 to March 2020 among restaurant workers in Gondar city. A two-stage sampling technique was used to choose 633 study subjects. A structured Nordic questioner was used to collect the data. Data was entered into EpiData version 3.1 and exported to Stata version 14.0 for analysis. Both bivariable and multivariable logistic regression analyses were computed. An adjusted odds ratio with a 95% confidence interval was used to measure tts. Age above 30 years, educational status being primary and secondary, and being dissatisfied by their job were positively associated with a high prevalence of WMSDs.Noncommunicable diseases (NCDs) are posing a great threat to mankind. Timely identification, prevention, and control of common risk factors help to reduce the burden of death from NCDs. These risk factors are also closely related to lifestyle changes. This study aimed to assess the prevalence of risk factors of NCDs among semiurban population of Kavre district. Community-based cross-sectional study design using the multistage sampling method was used to select 456 respondents. Data were collected using WHO’s STEPS instruments 1 and 2. Four behavioural risk factors, i.e., current tobacco use, harmful alcohol use, physical inactivity, and inadequate servings of fruits and vegetables and two metabolic risk factors, i.e., abdominal obesity and hypertension were included in the study. The study revealed that more than one-third (36.0%; 43.0-52.2%) were current tobacco users, nearly one-sixth (15.8%; 12.7-19.4%) consumed alcohol harmfully, most of all did not have adequate servings of fruits and vegetables (95.8%; 93.6-97.3%), nearly two-thirds have abdominal obesity (62.1%; 57.5-66.4%), and more than one-fifth of population had hypertension (22.1%; 18.6-26.2%). Only 1.1% respondents were free from risk factors, while 78.5%, 46.1%, 14.5%, and 1.8% had two, three, four, and five risk factors, respectively. The co-occurrence of three or more risk factors was associated with increasing age (AOR ranging 4.7-10.9), male sex (AOR = 3.9 (2.4-6.3); p less then 0.001), and illiterate respondents (AOR = 1.7 (1.0-2.9); p=0.038). The study concludes that almost all adults residing in semiurban areas of Kavre district have at least one or more risk factors, and nearly half of them have three or more risk factors. This suggests appropriate preventive approaches to be focused on younger age groups, male sex, and illiterate population to reduce the prevalence of NCDs in the near future.