ubspecialists. Early recognition, evaluation, and management will facilitate care and improve outcomes. Further research into its natural history with common progression to migraine headaches, neuroendocrine mechanisms, and the pathophysiologic relation to migraine diathesis is much needed.

Despite improved characterization and understanding, CVS remains classified as a functional disorder of brain-gut interaction that is often disjointly managed by generalists and subspecialists. Early recognition, evaluation, and management will facilitate care and improve outcomes. Further research into its natural history with common progression to migraine headaches, neuroendocrine mechanisms, and the pathophysiologic relation to migraine diathesis is much needed.

Radiochromic film has been established as a detector that can be used without the need for perturbation correction factors for small field dosimetry in water. However, perturbation factors in low density media such as lung have yet to be published. This study calculated the factors required to account for the perturbation of radiochromic film when used for small field dosimetry in lung equivalent material.

Monte Carlo simulations were used to calculate dose to Gafchromic EBT3 film when placed inside a lung phantom. The beam simulated had a nominal energy of 6MV and the field sizes simulated ranged from 10×10mm

to 30×30mm

. learn more The lung density simulated was varied between 0.2 and 0.3g/cm

. Each simulation was repeated with the film replaced by lung material (the same as the surrounding medium), and the required correction factors for film dosimetry in lung (

D

M

e

d

,

Q

will increase if either the density or the field size decrease further. This correction factor does not vary as a function of depth in lung once charged particle equilibrium is established.

To establish a framework for the standardization of monitoring radiotherapy protocol compliance.

An automated protocol compliance tool was developed using best practice in software design and a flexible framework to easily adapt to changing institutional standards. The Eclipse scripting environment was used to develop the application with the scripting application programing interface (API) and direct data extraction from ARIA. For each institutional protocol, external validation was specified in a JavaScript Object Notation (JSON) file that stores protocol specific constraints and evaluates compliance of the data from Eclipse and Aria. This tool was applied prospectively to a cohort of prostate cancer patients undergoing radiotherapy with a prescription regimen of 60Gy in 20 fractions.

The prospective evaluation was performed on 58 prostate cancer patients. For this cohort, the mean (standard deviation) pass rate is 92.3% (6.1%). The overall fail rate is 6.0% (5.8%); the percentage of these failures is in 2.6% in Patient Assessment, 0% in Simulation, and 97.4% in Treatment Planning.

A protocol compliance application is developed and implemented in a standard radiotherapy information system. The application functionality is demonstrated on a cohort of 58 patients undergoing prostate radiotherapy, which highlights the utility of assessing adherence to institutional protocols. A unified method must be available for the community to ensure consistency in compliance reporting.

A protocol compliance application is developed and implemented in a standard radiotherapy information system. The application functionality is demonstrated on a cohort of 58 patients undergoing prostate radiotherapy, which highlights the utility of assessing adherence to institutional protocols. A unified method must be available for the community to ensure consistency in compliance reporting.

The initial wave of the Covid-19 pandemic has hit Italy, and Lombardy in particular, with violence, forcing to reshape all hospitals’ activities; this happened even in pediatric hospitals, although the young population seemed initially spared from the disease. “Vittore Buzzi” Children’s Hospital, which is a pediatric/maternal hospital located in Milan (Lombardy Region), had to stop elective procedures-with the exception of urgent/emergent ones-between February and May 2020 to leave space and resources to adults’ care. We describe the challenges of reshaping the hospital’s identity and structure, and restarting pediatric surgery and anesthesia, from May on, in the most hit area of the world, with the purpose to avoid and contain infections. Both patients and caregivers admitted to hospital have been tested for Sars-CoV-2 in every case.

Observational cohort study via review of clinical charts of patients undergoing surgery between 16th May and 30th September 2020, together with SARS-CoV -2 RT-PCR testing outcomes, and comparison to same period surgeries in 2019.

An increase of approximately 70% in pediatric surgeries (OR 1.68 [1.33-2.13], P<.001) and a higher increase in the number of surgeries were reported (OR 1.75 (1.43-2.15), P<.001). Considering only urgent procedures, a significant difference in the distribution of the type of surgery was observed (Chi-squared P-value<.001). Sars-CoV-2-positive patients have been 0.8% of total number; 14% of these was discovered through caregiver’s positivity.

We describe our pathway for safe pediatric surgery and anesthesia and the importance of testing both patient and caregiver.

We describe our pathway for safe pediatric surgery and anesthesia and the importance of testing both patient and caregiver.Sex hormones, including androgens and estrogens, play an important role in autonomic, reproductive and sexual behavior. The areas that are important in these behaviors lie within the spinal cord and brainstem. Relevant dysfunctional behavior in patients with altered androgen availability or androgen receptor sensitivity might be explained by the distribution of androgens and their receptors in the central nervous system. We hypothesize that autonomic dysfunction is correlated with the androgen sensitivity of spinal cord and brainstem areas responsible for autonomic functions. In this study, androgen receptor immunoreactive (AR-IR) nuclei in the spinal cord and brainstem were studied using the androgen receptor antibody PG21 in four uncastrated young adult male cats. A dense distribution of AR-IR nuclei was detected in the superior layers of the dorsal horn, including lamina I. Intensely stained nuclei, but less densely distributed, were found in lamina X and preganglionic sympathetic and parasympathetic cells of the intermediolateral cell column.