There were 37 studies registered, 15 contained a protocol, and two stated actively that they were willing to share data. Most studies provided a statement about funding and conflicts of interest. Two articles explicitly described themselves as replications. All randomized controlled trial published in REI journals were registered prospectively; many meta-analyses were not registered. High-impact journal articles had a greater median sample size and more citations and were more likely to be registered, to have a protocol, and to claim novelty explicitly when compared with REI 2013 and 2018 articles.

Research in REI can be improved in prospective registration, routine availability of protocols, wider sharing of raw data whenever feasible, and more emphasis on replication.

Research in REI can be improved in prospective registration, routine availability of protocols, wider sharing of raw data whenever feasible, and more emphasis on replication.

Cervical cancer can be avoided with smear screening, and since 2006 with vaccination against papillomavirus. Yet, vaccination coverage remains very low in France. click here We aimed to highlight the perceptions and feelings of young girls regarding papillomavirus vaccination, to initiate a discussion and find ways to promote this vaccination.

Qualitative study with semi-directed interviews, until data saturation, and using grounded theory, with volunteer girls aged 11-14 years in a French department from September to December 2016.

Thirty-four young girls were interviewed. Their opinion of anti-HPV vaccination was not negative. Knowledge of papillomavirus vaccination was better in those aged above 12 years, in urban areas, and in those vaccinated against hepatitis B. Young girls with parents working in the medical field seemed to be more involved in the vaccination process. Nevertheless, we observed a clear lack of knowledge or misbeliefs. Parents, especially mothers, were the most important source of information for girls. Family physicians played an essential role in the vaccination decision-making process.

Girls seem to be barely involved in the vaccination process. However, this vaccination is based on the young girl/parents/physician trio. All healthcare professionals should be trained so as to have a scientifically valid speech on vaccination. Family physicians play a central part. Comprehensive and adequate information should be provided to girls and parents.

Girls seem to be barely involved in the vaccination process. However, this vaccination is based on the young girl/parents/physician trio. All healthcare professionals should be trained so as to have a scientifically valid speech on vaccination. Family physicians play a central part. Comprehensive and adequate information should be provided to girls and parents.

Maximal, aggressive resection of diffuse low-grade gliomas (DLGG) is well established as the standard of care in neuro-oncology. The role of repeat resection for tumor progression is unclear.

To assess the role of repeated operation for DLGG, and the effect on malignant transformation and survival.

We conducted a historical cohort study in which all patients undergoing multiple resections of DLGG between the years 1995-2019 were evaluated for overall survival (OS) and time to transformation (TTT). We then compared the outcome of this group with that of a matched control group comprised of patients who underwent only one operation despite being eligible for repeat surgery at tumor progression, but had received non-surgical oncological therapy or declined additional treatment.

Of 607 patients in our departmental DLGG database, 93 patients underwent 2 or more surgeries and had sufficient follow-up and imaging data to be included in the study group. Thirty-eight patients were included in the matched control group. Early (less than 1 year) progression was associated with decreased survival and shorter TTT in the study group. Patients undergoing multiple resections had significantly longer TTT and OS compared to patients who underwent a single surgery. This effect was especially noted in patients who had radiological evidence of tumor transformation.

Repeated resections of LGG are safe and offer survival benefit in select patients. Early progression following resection is associated with worse prognosis. Patients with evidence of radiological transformation may benefit the most from re-resection.

Repeated resections of LGG are safe and offer survival benefit in select patients. Early progression following resection is associated with worse prognosis. Patients with evidence of radiological transformation may benefit the most from re-resection.

Low protein intake and increased muscle breakdown are associated with increased mortality risk in patients with kidney transplantation (KT). 3-methylhistidine (3-MH), a nonproteinogenic amino acid residue, is an index of muscle breakdown. the present study investigated the association between serum 3-MH levels and subsequent first hospitalization events in patients with KT.

A total of 64 KT patients were enrolled and 43 first hospitalization events occurred. Fasting blood samples were obtained and serum 3-MH level was performed with high-performance liquid chromatography and mass spectrometry. Associations between serum 3-MH levels and first hospitalization over a 5-year follow-up period were examined.

Compared with patients without hospitalization, the 64 patients with KT revealed higher diabetes (P= .012) and hypertension (P= .006) prevalence, higher body fat mass (P= .012) and systolic blood pressure (P= .002), higher serum blood urea nitrogen (BUN) levels (P= .003), and lower serum 3-MH levels (P= .001). Statistical analysis revealed that serum 3-MH (95% confidence interval [CI] 0.902-0.986, P= .010) and serum BUN (95% CI 1.003-1.040, P= .022) levels were independently associated with first hospitalization events in patients with KT. Kaplan-Meier analysis showed a greater cumulative incidence of first hospitalization events in the patients with lower 3-MH levels (≤5.91 ng/mL) than that in those with higher 3-MH levels (P= .014; log-rank test).

Low serum 3-MH levels are associated with increased first hospitalization risk in KT recipients.

Low serum 3-MH levels are associated with increased first hospitalization risk in KT recipients.