RV functional change with regional difference may reflect the heterogeneity of volume reduction and suggest subclinical RV dysfunction. These findings can enhance our understanding of the physiologic changes in the RV during reverse remodeling.Surfactant tolerance in the presence of mono and divalent reservoir ions, as well as the solubility of surfactant in high salinity and low salinity brine, are the two major requirements for any surfactant that is subjected to oilfield application. Herein, six poly(ethylene oxide) zwitterionic surfactants having different ionic headgroups and hydrophobic tail were synthesized for oilfield applications. They were characterized by various instrumental techniques (Fourier-transform infrared spectroscopy (FTIR), matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-ToF-MS), Nuclear Magnetic Resonance (NMR)) and the combination of these techniques allowed for us to deduce the structure. All of the surfactants revealed prominent solubility in high salinity and low salinity brine due to the presence of ethoxy units between the aromatic ring and amide group. The surfactant samples were oven aged for 90 days at reservoir temperature and a clear solution implies their excellent aqueous stability. Rendering to thermal gravimetric results, decomposition of surfactants was found to occur around 300 °C, which is higher than the reservoir temperature (≥90 °C). It was observed that the hydrophilic headgroup has no significant impact on the critical micelle concentration and other surface properties. However, the hydrophobic tail bearing benzene ring significantly alters the critical micelle concentration and other surface properties.Accumulating evidence from animal and human studies supports the notion that physical exercise can enhance neuroplasticity and thus reduce the risk of several neurodegenerative diseases (e.g., dementia). However, the underlying neurobiological mechanisms of exercise induced neuroplasticity are still largely unknown. One potential mediator of exercise effects is the neurotrophin BDNF, which enhances neuroplasticity via different pathways (e.g., synaptogenesis, neurogenesis, long-term potentiation). Current research has shown that (i) increased peripheral lactate levels (following high intensity exercise) are associated with increased peripheral BDNF levels, (ii) lactate infusion at rest can increase peripheral and central BDNF levels and (iii) lactate plays a very complex role in the brain’s metabolism. In this review, we summarize the role and relationship of lactate and BDNF in exercise induced neuroplasticity.A methodology for obtaining the optimal structure and distribution for the gradient properties of a material in order to reduce the stress level in a soldered joint was constructed. The developed methodology was based on a combination of topological optimization methods (the moving asymptotes method) and the finite elements method; it was first implemented to solve problems of optimizing soldered joints. Using the proposed methodology, a number of problems were solved, allowing one to obtain optimal structural characteristics, in which a decrease in stress is revealed. Designing compounds using this technique will provide more robust designs. The proposed technique can be applied to a wide class of practical problems.The purpose of this study was to comprehensively analyze the effects of the carbon powder coating mass fraction, pressure, reduction temperature, reduction time, gas linear velocity, and particle size on fluidization reduction. Brazilian fine iron ore particles were the experimental object, and reduction experiments were performed under added carbon powder coating and pressure conditions. A six-factor, three-level orthogonal experiment method was used to obtain the optimal operating conditions and investigate the adhesion and inhibition mechanisms of fine iron ore during reduction. The experimental results show that with the addition of a carbon powder coating, an appropriate increase in pressure can increase the metallization rate, improve the fluidization state, and reduce the sticking ratio. The optimal operating conditions for pure hydrogen to reduce Brazilian fine iron ore was found to be a reduction temperature of 923-1023 K, the linear velocity of the reducing gas was 0.6 m/s, the reducing time was 30-50 min, the reducing pressure was 0.25 MPa, the mass content of the coated carbon powder was 2-6% (accounting for the mass of the mineral powder), and the particle size of the carbon powder was 4-7 µm. Akt inhibitor Iron whiskers cohesion and agglomeration were the main reasons for the adhesion of ore powder particles. It was found that carbon powder coating can effectively change the morphology of metal iron, as metal iron generates spherical particles around the carbon powder to improve the fluidization state.Patients with glioblastoma are at high risk of local recurrences after initial treatment with standard therapy, and recurrent tumor cells appear to be resistant to first-line drug temozolomide. Thus, finding an effective second-line agent for treating primary and recurrent glioblastomas is critical. Betulinic acid (BA), a natural product of plant origin, can cross the blood-brain barrier. Here, we investigated the antitumor effects of BA on typical glioblastoma cell lines and primary glioblastoma cells from patients, as well as corresponding temozolomide-resistant cells. Our findings verified that BA significantly reduced growth in all examined cells. Furthermore, gene-expression array analysis showed that the unfolded-protein response was significantly affected by BA. Moreover, BA treatment increased activation of the protein kinase RNA-like endoplasmic reticulum kinase (PERK)/C/EBP homologous protein (CHOP) apoptotic pathway, and reduced specificity protein 1 (Sp1) expression. However, Sp1 overexpression reversed the observed cell-growth inhibition and PERK/CHOP signaling activation induced by BA. Because temozolomide-resistant cells exhibited significantly increased Sp1 expression, we concluded that Sp1-mediated PERK/CHOP signaling inhibition protects glioblastoma against cancer therapies; hence, BA treatment targeting this pathway can be considered as an effective therapeutic strategy to overcome such chemoresistance and tumor relapse.