Furthermore, the challenges and prospects for future development of nanocellulose-based materials in biomedical applications are also discussed at the end in the review.We retrospectively analyzed all endovascular procedures of infrapopliteal arterial lesions (n = 383) performed in 270 patients at our institution between December 2008 and January 2018. The overall technical success rate was 97% and yielded 98% for stenoses (n = 214) and 95% for occlusions (n = 169). Trans-Atlantic Inter-Society Consensus (TASC II) classification had no impact on success rates (TASC A + B vs C + D; 96.5% vs 96.9%, p = 0.837). Freedom from clinically driven target lesion revascularization (TLR) after 6 and 12 months was 88.3% and 77.2%. TLR was comparable for TASC A to C lesions and no difference was observed comparing groups of moderately complex TASC A/B lesions and more complex TASC C/D lesions (TASC A + B vs C + D; 78.5% vs 74.2%, p = 0.457). Freedom from TLR was significantly lower in very complex TASC D lesions (TASC A + B + C vs D; 79.7% vs 42.5%, p less then 0.001). Multivariate analysis identified TASC D lesions (hazard ratio D/A 1.5; overall p = 0.002), Fontaine class III and IV (hazard ratio III or IV/IIa or IIb 2.4; p = 0.041), and occlusive lesions (hazard ratio occlusion/stenosis 2.4; p = 0.026) as predictors for TLR. In conclusion, endovascular therapy for infrapopliteal artery disease was safe and accompanied with a promising long-term outcome.Forced coexpression of the transcription factors Oct3/4, Klf4, Sox2, and c-Myc reprograms somatic cells into pluripotent stem cells (PSCs). Such induced PSCs (iPSCs) can generate any cell type of the adult body or indefinitely proliferate without losing their potential. Accordingly, iPSCs can serve as an unlimited cell source for the development of various disease models and regenerative therapies for animals and humans. Although canine peripheral blood mononuclear cells (PBMCs) can be easily obtained, they have a very low iPSC reprogramming efficiency. NSC 309132 In this study, we determined the reprogramming efficiency of canine PBMCs under several conditions involving three types of media supplemented with small-molecule compounds. We found that canine iPSCs (ciPSCs) could be efficiently generated from PBMCs using N2B27 medium supplemented with leukemia inhibitory factor (LIF), basic fibroblast growth factor (bFGF), and a small-molecule cocktail (Y-27632, PD0325901, CHIR99021, A-83-01, Forskolin, and l-ascorbic acid)ul for disease modeling and regenerative medicine in the veterinary field.Globally Unwanted pregnancy is a health related problem that affects girls, their families and social order. Of an estimated 210 million pregnancies that take place in the world each year, 38% are unwanted, out of which 22% end up with abortion. Unwanted pregnancy among teenagers is a serious risk health related problem in Ethiopia. Therefore, the aim of this study was to assess the prevalence and causes of unwanted pregnancy in Woldia University. 121 graduating class of technology Faculty, students was selected by using availability (convenient) sampling techniques. Questionnaire having both open ended and close ended items was developed and administrated for participants. The research was mixed in its nature, including both quantitative and qualitative approaches. The findings of this survey indicated that the bulk of the respondents were using whatever type of contraceptive methods like condom and oral contraceptives.Majorities of them used their allies as the major source of data. From the participants of this study, the majority of them have been fraught. Drinking alcohol and peer pressure were mentioned as a major cause of unwanted pregnancy. The majority of students have experienced an unwanted pregnancy in their campus life, but too little attention given by the university. Thus, university gender directorate office, student union, spiritual leadership, student dean and counselors should work together to minimize the trouble.

Hypertension is a major public health threat affecting adults worldwide. The low hypertension management knowledge causes uncontrolled high blood pressure and it’s a complication. It requires patients with uncontrolled hypertension to increase adherence to either pharmacological therapy or nonpharmacological therapy aimed at achieving normal blood pressure.

The purpose of this study was to examine the effectiveness of a short-term educational program on hypertension management related knowledge and attitude among uncontrolled hypertension patients in Malang, Indonesia.

The research design used a Quasi-Experimental study with the design of one group pre-post-test. The participants were 41 uncontrolled hypertension patients chosen by purposive sampling at the Ciptomulyo Public Health Center. The questionnaires were used to collect the data. The

(HK-LS) questionnaire was used to determine the knowledge of uncontrolled hypertension patients. KAP questionnaire was used to determine the attitude of the participants. The data were analyzed statistically using the

The majority of respondents were aged 55-65 (54%), female (83%), housewife (76%), graduated elementary school (71%), and long suffered from hypertension >1 year (68%). The result showed that the provision of the educational program increases knowledge (p = 0,000) and attitude (p = 0,008) of patients on the management of hypertension.

Health education could improve hypertension management knowledge and attitude among uncontrolled hypertension in the rural area. Furthermore, Health providers should consider giving the education among uncontrolled hypertension.

Health education could improve hypertension management knowledge and attitude among uncontrolled hypertension in the rural area. Furthermore, Health providers should consider giving the education among uncontrolled hypertension.Background Mitochondrial stress is known to activate the mitochondrial unfolded protein response (UPRmt). The UPRmt results in the secretion of mitochondrial cytokines (mitokines), which can promote a hormetic response cell nonautonomously, and has been reported to be protumorigenic. Growth differentiation factor 15 (GDF15) is a well-characterized mitokine, which is reported to have a mitohormetic effect. Thus, we investigated whether GDF15 induction could prime a subpopulation of thyroid cancer cells to provide invasive advantages. Methods The UPRmt, including mitokine expression, was assessed in the context of thyroid cancer in vitro and in vivo. GDF15 expression in 266 patients with papillary thyroid carcinoma (PTC) was determined by immunohistochemistry. The serum levels of GDF15 were measured in healthy subjects and PTC patients. In addition, our own and The Cancer Genome Atlas data were analyzed to determine the expression level of GDF15 in thyroid cancers. The role of GDF15 in tumor aggressiveness was investigated by observing the effects of GDF15 knockdown in BCPAP, TPC-1, 8505C, and FRO cells.