BACKGROUND People with intellectual disabilities who live in residential facilities may need social support to express self determination. Relationships with social care professionals provide an important context for promoting self-determination. Glucagon Receptor peptide Adopting a socioecological perspective, our study aimed to better understand the nature of these relationships. METHOD Over a period of ten months, we held 13 focus group discussions with a total of 20 participants, including both residents and staff at facilities for people with intellectual disabilities. Using transcripts of these discussions, we analysed expressions of self-determination among people with intellectual disabilities and the responses of social care professionals. RESULTS Our results highlight the importance of relational adjustment in fostering self-determination among people with intellectual disabilities and underline the importance of respective roles within relationships between people with intellectual disabilities and social care professionals. CONCLUSION The partnership between people with intellectual disabilities and professionals seems to be the most effective type of relationship in order to support the self-determination of people with intellectual disabilities. This paper provides a fresh perspective on the role played by people with intellectual disabilities in their relationships with social care professionals. By engaging people with intellectual disabilities as partners in fostering self-determination, social care professionals can encourage social participation and feelings of empowerment. Relationships based on partnership offer people with intellectual disabilities a form of hetero-regulation that can help them overcome challenges to behaving in a fully self-determined way. However, partnership also requires changes in professional practices and attitudes. The molecular structure of a crosslinked nitrogen-rich resin made from melamine, urea, and aldehydes, and of microcapsules made from the reactive resin with multiple polymeric components in aqueous dispersion, has been analyzed by 13C, 13C1H, 1H-13C, 1H, 13C14N, and 15N solid-state NMR without isotopic enrichment. Quantitative 13C NMR spectra of the microcapsules and three precursor materials enable determination of the fractions of different components. Spectral editing of non-protonated carbons by recoupled dipolar dephasing, of CH by dipolar DEPT, and of C-N by 13C14N SPIDER resolves peak overlap and helps with peak assignment. It reveals that the N- and O-rich resin “imitates” the spectrum of polysaccharides such as chitin, cellulose, or Ambergum to an astonishing degree. 15N NMR can distinguish melamine from urea and guanazole, NC=O from COO, and primary from secondary amines. Such a comprehensive and quantitative analysis enables prediction of the elemental composition of the resin, to be compared. OBJECTIVES/BACKGROUND Rapid eye movement (REM) Sleep Behavior Disorder (RBD) in Parkinson’s disease (PD) may be associated with a malignant phenotype. Despite its prognostic value, little is known about the time course of RBD in PD. In this study, we aimed to ascertain whether or not RBD is a stable feature in PD. In this study, we prospectively evaluated clinical and neurophysiological features of RBD, including REM Sleep Without Atonia (RSWA), in PD patients with RBD at baseline and after three years then assessed whether the changes in measures of RSWA parallel the progression of PD. PATIENTS/METHODS In sum, 22 (17M, mean age 64.0 ± 6.9 years) moderate-to-advanced PD patients (mean PD duration at baseline7.6±4.8 years) with RBD, underwent a video-polysomnography (vPSG) recording and clinical and neuropsychological assessment at baseline and after three years. RESULTS At follow-up, the self-assessed frequency of RBD symptoms increased in six patients, decreased in six and remained stable in 10, while RSWA measures significantly increased in all subjects. At follow-up, patients showed worse H&Y stage (p = 0.02), higher dopaminergic doses (p = 0.05) and they performed significantly worse in phonetic and semantic fluency tests (p = 0.02; p = 0.04). Changes in RSWA correlated significantly with the severity in levodopa-induced dyskinesia (r = 0.61,p = 0.05) and motor fluctuation (r = 0.54,p = 0.03) scores, and with the worsening of executive functions (r = 0.78,p = 0.001) and visuo-spatial perception (r = -0.57,p = 0.04). CONCLUSION Despite the subjective improvement of RBD symptoms in one-fourth of PD patients, all RSWA measures increased significantly at follow-up, and their changes correlated with the clinical evolution of motor and non-motor symptoms. RBD is a long-lasting feature in PD and RSWA is a marker of the disease’s progression. OBJECTIVE In this study, we investigated differences in sleep patterns between obese and non-obese adolescents, and determined which sleep-related parameters were associated with a risk of adolescent obesity. METHODS In this cross-sectional study, we evaluated 22,906 adolescents between 12 and 18 years of age (mean 15.2 ± 1.7 years; male 50.9%). Self-report questionnaires were used to assess body mass index (BMI) and sleep habits. Obesity was defined as a BMI-for-age ≥ 95th percentile. Weekend catch-up sleep (CUS) duration was calculated as the sleep duration on free days minus sleep duration on school days. We estimated mid-sleep time on free days corrected for oversleep on free days (MSFsc) and social jet lag. Then, we performed multivariate analysis for adolescent obesity and BMI, respectively. RESULTS The prevalence of obesity was 6.0%. The average sleep duration (P = 0.017) and weekend CUS duration (P  less then  0.001) of obese adolescents were shorter than those of non-obese adolescents. However, there was no significant difference in MSFsc or social jet lag by the obesity status. After adjustment, obesity was significantly associated with short average sleep duration (odds ratio [OR] 0.91, 95% confidence interval [CI] 0.86-0.96) and short weekend CUS duration (OR 0.92, 95% CI 0.89-0.95). Similarly, BMI was inversely correlated with average sleep duration (B = -0.15, 95% CI -0.19 to -0.11) and weekend CUS duration (B = -0.09, 95% CI -0.11 to -0.06). CONCLUSIONS Our observations suggest that short sleep duration, rather than late MSFsc or social jet lag, was associated with adolescent obesity. V.