These nanocapsules possessed extremely weak cellular interaction and could avoid uptake by endothelial cells (HUVEC), immune cells (RAW 264.7), and tumor cells (H22), selectively depriving extracellular arginine. Besides, these nanocapsules increased the blood half-life time of ADI from the initial 2 h to 90 h and efficiently avoided its immune or inflammatory responses. After a single injection of ADI nanocapsules into H22 tumor-bearing mice, tumors were stably suppressed for 25 d without any detectable side effects. This new strategy first realizes the selective extracellular arginine deprivation for the treatment of ASS1-deficient tumors, potentially promoting the clinical translation of metabolic enzyme-based amino acid deprivation therapy. Furthermore, the research reminds us that the functionalization of drugs can not only improve its weakness but also maintain its advantages.Spin hyperpolarization can dramatically increase signal intensities in magnetic resonance experiments, providing either improved bulk sensitivity or additional spectroscopic detail through selective enhancements. While typical hyperpolarization approaches have utilized microwave irradiation, one emerging route is the use of optically generated triplet states. We report an investigation into the effects of solution viscosity on radical-triplet pair interactions, propose a new standard for quantification of the hyperpolarization in EPR experiments, and demonstrate a significant increase in the optically generated 1H NMR signal enhancement upon addition of glycerol to aqueous solutions.Tripodal ligands with main group bridghead units are well established in coordination chemistry and single-site organometallic catalysis. Although a large number of tris(2-pyridyl) main group ligands [E(2-py)3] (E = main group element, 2-py = 2-pyridyl) spanning across the whole p-block are now synthetically acessible, only limited work has been done on the coordination chemistry on the tris(2-pyridyl) group 15 ligands for the heavier elements (As, Sb). In the current study we investigate the coordination chemistry of the ligand family E(6-Me-2-py)3 (E = As, Sb) and of the As(v) ligand O[double bond, length as m-dash]As(6-Me-2-py)3. The air- and mositure-stability of all of these main group ligands makes them especially attractive in future catalytic applications.The development of low-cost, high-activity, durable non-precious metal bifunctional electrocatalysts is of great importance in the production of hydrogen by water electrolysis. In this work, we have prepared new Al-doped Ni3S2 nanosheet arrays grown on Ni foam (Al-Ni3S2/NF) as an excellent bifunctional electrocatalyst in the hydrogen evolution reaction (HER) and oxygen evolution reaction (OER). The Al-Ni3S2/NF electrode obtained only requires extremely low overpotentials of 86 and 223 mV for the HER and OER to achieve a current density of 10 mA cm-2 in 1 M KOH, respectively. Moreover, the electrolytic cell assembled using this electrode as both cathode and anode provides a current density of 10 mA cm-2 at an extremely low battery voltage of 1.58 V relative to that with Ni3S2/NF (1.71 V). Additionally, both experimental results and theoretical calculations reveal that the increased electrochemical active surface area and optimized intermediate adsorption free energies are responsible for the enhanced electrocatalytic performance. This work provides a promising bifunctional electrocatalyst for water electrolysis in alkaline media with broad application prospects.Human carboxylesterase 2 (hCES2A) is a key target to ameliorate the intestinal toxicity triggered by irinotecan that causes severe diarrhea in 50%-80% of patients receiving this anticancer agent. Herbal medicines are frequently used for the prevention and treatment of the intestinal toxicity of irinotecan, but it is very hard to find strong hCES2A inhibitors from herbal medicines in an efficient way. Herein, an integrated strategy via combination of chemical profiling, docking-based virtual screening and fluorescence-based high-throughput inhibitor screening assays was utilized. Following the screening of a total of 73 herbal products, licorice (the dried root of Glycyrrhiza species) was found with the most potent hCES2A inhibition activity. Further investigation revealed that the chalcones and several flavonols in licorice displayed strong hCES2A inhibition activities, while isoliquiritigenin, echinatin, naringenin, gancaonin I and glycycoumarin exhibited moderate inhibition of hCES2A. Inhibition kinetic analysis demonstrated that licochalcone A, licochalcone C, licochalcone D and isolicoflavonol potently inhibited hCES2A-mediated fluorescein diacetate hydrolysis in a reversible and mixed inhibition manner, with Ki values less than 1.0 μM. Further investigations demonstrated that licochalcone C, the most potent hCES2A inhibitor identified from licorice, dose-dependently inhibited intracellular hCES2A in living HepG2 cells. In summary, this study proposed an integrated strategy to find hCES2A inhibitors from herbal medicines, and our findings suggested that the chalcones and isolicoflavonol in licorice were the key ingredients responsible for hCES2A inhibition, which would be very helpful to develop new herbal remedies or drugs for ameliorating hCES2A-associated drug toxicity.Accurate thermal sensing with good spatial resolution is currently required in a variety of scientific and technological areas. TI17 Luminescence nanothermometry has shown competitive superiority in contactless temperature sensing, especially at the nanoscale. To broaden the use of such thermometers, development of a novel sensor type with high sensitivity and resolution is highly demanded. Herein, we report single-phase Ln3+-doped YVO4 nanophosphors synthesized using a modified Pechini method as multimode optical thermometers for wide-range temperature probing (299-466 K). The observed temperature-induced red shift of the charge transfer band was utilized to provide thermal sensing. Temperature sensing was based on the luminescence intensity ratio using emission intensities obtained upon charge transfer and direct lanthanide excitation, the spectral position of the charge transfer band and its bandwidth. The suggested probing strategies provided a high relative thermal sensitivity (up to 3.09% K-1) and a precise temperature resolution (up to 0.