The cytotoxic effect analyzed by MTT assay showed that both compounds have effective antiproliferative on MCF-7 cell line. In addition, the inhibition effect of [Pt(DACH)(13DMPG)]NO3 (IC50 = 17 µM) was shown to be better than [Pt(bpy)(13DMPG)]NO3 (IC50 = 45 µM). find more According to DFT results, anticancer properties of [Pt(bpy)(13DMPG)]NO3 mainly is more than cisplatin and [Pt(DACH)(13DMPG)]NO3. Docking studies showed that the desolvation energy and hydrogen bond are more effective compared to the other interactions. The torsional free energy, about +1.19 kcal/mol, for both complexes mainly provides groove binding with partially electrostatic and intercalate bindings.An environment-friendly and economically sound method was developed to achieve a multi-functional ZnO nanoparticles (ZnO NPs) using water extract of Livistona jekinsiana. The ZnO NPs absorbed maximum wavelength of light at 332 nm in UV-Visible spectroscopy (UV/Vis). X-Ray Diffraction (XRD) pattern revealed the crystallinity of the nanoparticles with the crystallite size around 22.45 nm. The geometry, shape, size, and elemental composition were determined by Transmission Electron Microscope (TEM) and Energy Dispersive Spectroscopy (EDS). The presence of phytochemicals and the typical zinc-oxygen group in the ZnO NPs was implied by Fourier Transform Infrared spectroscopy (FTIR). Photo luminescence spectroscopy (PL), and Dynamic Light Scattering (DLS) techniques were also used to characterize and study the different features of ZnO NPs. The multifunctional ZnO NPs showed an efficient photodegradative effect towards the degradation of two anthropogenic dyes, methyl orange (MO) and methylene blue (MB) under solar radiation. The degradation reaction of MO and MB was compliantwithzero-order kinetics and first-order kinetics respectively. Also, Livistona jekinsiana fabricated ZnO NPs showed potential Antibacterial activity against S. aureus, B. subtilis, E. coli and K. pneumonia bacteria and effective antioxidant activity using DPPH scavenging assay. The mechanism of the antibacterial activity was established by estimating the ROS generation and percentage of DNA in K. pneumonia cell. The study illustrated the reducing and stabilizing property of the Livistona jekinsiana extract as a novel source and potential photodegradative and therapeutic effects of the ZnO NPs.One third of depressive patients do not achieve remission after several steps of treatment and are considered as treatment resistant. Electroconvulsive therapy (ECT) improves symptoms in 70 to 90% of such cases. Resistant depression is associated with a dysregulation of the immune system with a dysbalance between the pro- and the anti-inflammatory cytokines. Therefore, we aimed to measure the kinetic of cytokines levels before, during and at the end of ECT. To test this hypothesis, we performed a meta-analysis assessing cytokines plasma levels before, during and after ECT in patients with major depressive disorders. After a systematic database search, means and standard deviations were extracted to calculate standardized mean differences. We found that IL-6 levels increased after 1 or 2 ECT session (p = 0.01) then decrease after 4 ECT sessions (p less then 0.01) with no difference at the end of ECT (p = 0.94). A small number of studies were included and there was heterogeneity across them. The present meta-analysis reveals that ECT induces an initial increase of IL-6 levels and a potential decrease of TNF-α levels. No changes on IL-4 and IL-10 levels were found. Further work is necessary to clarify the impact of ECT on peripheral cytokines.

Minor head trauma in the child, whether accidental or inflicted, is a frequent reason for seeking medical attention. Our aim is to describe the characteristics of minor head trauma in children aged 0-3 years and the resulting injuries. This in order to help the clinician to suspect and thelegal expert to confirm intentional abuse.

Children aged from 0 to 3 years with minor head trauma and attending the pediatric emergency department were included in the study between January 2013 and June 2014. The correlation between the characteristics of trauma and the resulting injuries was analyzed using a prospective data collection questionnaire completed by the physicians who cared for the child.

A total of 709 children with minor head trauma were included in the study. In nearly 90% of cases, fall height was less than 1 m. Only one-third of children aged less than 6 months had external head injury. Low-intensity trauma, such as a low-velocity fall from a height of less than 1.5 m does not cause intracranial injury. External injuries were more frequent in children who had a fall with an anterior impact, while internal injuries were found only in posterior and lateral impacts.

In the context of minor head trauma, the physician must be vigilant and must ask for a full and clear description of the trauma, its mechanisms and other characteristics, when external or internal head injuries are observed in children aged less than 6 months.

In the context of minor head trauma, the physician must be vigilant and must ask for a full and clear description of the trauma, its mechanisms and other characteristics, when external or internal head injuries are observed in children aged less than 6 months.The past decade has seen a huge jump in the resolution and scale at which we can interrogate the three-dimensional properties of the genome. This revealed different types of chromatin structures including topologically associating domains, partitioning genes and their enhancers into interacting domains. While the visualisation of these topologies and their dynamics has dramatically improved, our understanding of their underlying mechanisms and functional roles in gene expression has lagged behind. A suite of recent studies have addressed this using genetic manipulations to perturb topological features and loops at different scales. Here we assess the new biological insights gained on the functional relationship between genome topology and gene expression, with a particular focus on enhancer function.