women.IL-6 promotes T cell activation and production in acute inflammatory conditions, initiates B cell differentiation, regulates liver production of acute phase reactants, and stimulates hypothalamus-pituitary-adrenal system, which is important in acute inflammation. Nevertheless prolonged IL-6 exposition activates apoptosis. According to recent studies increased levels of IL-6 increase cardiovascular disease risks. The aim of the study was to explore IL-6 basic levels in chronic congestive heart failure patients, as in risk group in COVID-19, and various factors (demographic or clinical) in various groups of IL-6 basic levels. We used consecutive sampling approach to recruit 96 congestive heart failure patients and 34 persons without the condition as controls. Hematologic, biochemical and immunologic parameters were measured using conventional methods. We used descriptive statistics for demographic parameters. We compared mean values of hematologic and biochemical parameters in cases and controls using independent sample t test and explored differences within the congestive heart failure group (further separated in 3 groups according to IL-6 levels) using one way ANOVA test, with further post-hoc analysis. Levels of IL-6 are statistically significantly higher in CHF patients; groups differ in co-morbidity, also abdominal obesity is more prevalent in diseased group. Difference between groups is significant in a number of pro-inflammation, coagulation, hematology parameters. It is also important to note that the CHF group showed a number of differences in sub-groups according to IL-6 levels, risks of CHF and comorbidity deterioration risks therefore are suggested to be different.Purpose – to assess the probability of occurrence of the main cardiovascular events in the patients after revascularization interventions with a combined course of a stable coronary heart disease and non-alcoholic steatohepatitis (NASH) by indicators of fibrogenesis. 164 patients with stable coronary heart disease were observed, including 54 patients with NASH (a main group); 110 patients without NASH (a comparison group). All patients underwent general clinical examination, electrocardiography, coronary angiography, echocardiography, assessment of liver function, markers of fibrosis and long-term prognosis by the Kaplan-Meier method. It was found that the patients with stable coronary heart disease, combined with NASH, are characterized by the fibrosis progression, that is characterized by a significantly high value of fibrogenesis markers. The presence of NASH in patients with stable coronary heart disease causes a worsening of the disease and forms a negative prognosis in such patients in a two-year term. The prognosis of the patients who underwent coronary artery stenting depends on the course of non-alcoholic fatty liver disease and is the most prognostically unfavorable against the combination of the FIB-4 index ≥2.0 and NASH.One of the world’s most widely recognized and widely used questionnaires for assessing the impact of nasal diseases on the quality of life is sinonasal outcome test 22 (SNOT-22). The objective of the study was to develop the Ukrainian version of SNOT-22 questionnaire and to study its effectiveness while evaluating the impact of nasal diseases on quality of life of patients. The validity of the results obtained by using the Ukrainian version of SNOT-22 questionnaire was calculated by comparing the results obtained in the survey of patients with chronic rhinosinusitis (50), and patients with nasal septum deviation (50) with impaired nasal breathing, and two control groups (30 persons each) people with non-sinonasal symptoms and practically healthy people. The average results of SNOT-22 questionnaire for patients with chronic rhinosinusitis was 39.89 (SD=15.3), for patients with the nasal septum deviation it was 31.23 (SD=11.9). At the same time nonsinonasal patients, and control group representatives had the average SNOT-22 results 12.43(SD=4.5) and 10.34(SD=3,8), respectively. The Ukrainian version of SNOT-22 questionnaire is an effective statistical tool that can be used to study the impact of such a pathology as chronic rhinosinusitis and the nasal septum deviation on the quality of life of patients.The review considers one of the most important problems of modern otorhinolaryngology – the diagnosis of opportunistic mycoses. Data on the species spectrum of pathogens of opportunistic mycoses of the ENT organs and their epidemiology are presented, the analysis of existing methods of laboratory diagnosis of this pathology is given. The solution to the problem of rapid and reliable identification of fungi and determination of their sensitivity to antifungals is provided by the use of semi-automatic and automatic microbiological analyzers, as well as the use of mass spectrometry. Particular attention is paid to modern molecular genetic methods, such as polymerase chain reaction, sequencing of a new generation, which in combination with classical microbiological methods, make it possible, with the highest level of reliability, to identify microorganisms by species based on decoding their genomes. It also gives the possibility to assess the sensitivity of the isolated strains to chemotherapeutic drugs using the disco-diffusion method, the method of serial dilutions, epsilometric and the use of ATB strips. The introduction into clinical practice a set of classical and modern diagnostic technologies should become the standard for the diagnosis of fungal diseases not only upper respiratory tract and ear, but also other biotopes of the macroorganism.The aim of this study was to analyze the characteristics of physical and sexual development of patients with menstrual irregularities while monitoring over the past 20 years. Physical and sexual development of 497 patients with abnormal uterine bleeding (AMC PP) and 677 with hypomenstrual syndrome (HMS) aged 10 to 18 years were evaluated who were treated in the period 1997-2002 and 2010-2016. The data were compared with the results of epidemiological studies of a population of schoolgirls in Kharkov region. Monitoring of physical development of patients with menstrual dysfunction showed a significant deterioration in recent years. In modern girls with menstrual pathology, disharmony of physical development was recorded in almost every second, which is significantly more often than in the population and in relation to patients examined 15-20 years ago (р less then 0.001-0.0001). buy PF-07104091 Deviations in sexual development were recorded in more than half of patients with menstrual dysfunction. Moreover, its advance was much more often recorded in case of abnormal uterine bleeding at puberty, and lag in hypomenstrual syndrome.