Activation of TrkC by Nt-3 resulted in phosphorylation of the Igf1R on activating tyrosine residues in podocytes. Igf1R phosphorylation was increased in

mouse kidneys while it was decreased in

kidneys. Furthermore,

expression was elevated in glomerular tissue of patients with diabetic kidney disease compared with control glomerular tissue.

Our results show that

is essential for maintaining glomerular integrity. Furthermore, TrkC modulates Igf-related signaling in podocytes.

Our results show that TrkC is essential for maintaining glomerular integrity. Furthermore, TrkC modulates Igf-related signaling in podocytes.

Patients with lupus membranous nephropathy (LMN) are at risk for prolonged proteinuria and progressive chronic kidney disease. There are no proven effective treatments for LMN, and controlled trials are lacking. WAY309236A This trial assessed the preferential Janus kinase 1 (JAK1) inhibitor filgotinib and the spleen tyrosine kinase inhibitor lanraplenib in patients with LMN.

This was a phase II, randomised, double-blind trial conducted at 15 centres in the USA to evaluate the safety and efficacy of filgotinib or lanraplenib for the treatment of LMN. Eligible patients were randomised 11 to receive either filgotinib or lanraplenib in a blinded fashion for up to 52 weeks. The primary endpoint was the per cent change in 24-hour urine protein from baseline to week 16.

Nine patients were randomised to receive filgotinib (n=5) or lanraplenib (n=4). Four patients in the filgotinib group and one patient in the lanraplenib group completed week 16. There was a median reduction of 50.7% in 24-hour urine protein after 16 weeks of treatment with filgotinib (n=4), and the median Systemic Lupus Erythematosus Disease Activity Index from the Safety of Estrogens in Lupus National Assessment score remained stable. Filgotinib treatment was well tolerated. Limited conclusions can be drawn about treatment with lanraplenib.

The number of patients treated in this study was small, and only limited conclusions can be drawn. There may be a therapeutic benefit with filgotinib treatment, which may support future investigations with filgotinib or other JAK inhibitors in patients with LMN.

NCT03285711.

NCT03285711.The current pandemic has created a situation where nuclear medicine practitioners and medical physicists read or process nuclear medicine images remotely from their home office. This article presents recommendations on the components and specifications when setting up a remote viewing station for nuclear medicine imaging.Purpose18F-Sodium fluoride (NaF) PET/CT has a rapid single-pass extraction and fast clearance from soft tissues resulting in a better target to background ratio. This study aims to establish the optimum acquisition time and dosimetry of 18F-NaF PET/CT to evaluate bone metastases in obese patients. The secondary objective was to evaluate the impact of acquisition time on image quality, lesion detection rate, noise level, and radiation burden in this patient group. Material and Methods A total of sixty patients were included in the study (20 patients with body mass index (BMI) 30-35 kg/m2, 20 patients with BMI 35-40 kg/m2, and 20 patients with BMI >40 kg/m2). Images were acquired after intravenous (IV) injection of 0.06 mCi/kg (2.2 MBq/kg) 18F-NaF. Data was acquired in list mode using ordered subset expectation maximization (OSEM) reconstruction. The raw data could be re-binned to simulate scans with acquisition times of 2, 2.5, and 3-minutes per bed position. Scans were visually analyzed by two observers and ss assessed. However, it is recommended to do 3min per bed position acquisition in patients with BMI >40.Pakistan is a country with nuclear capability in a region sharing borders with 2 other nuclear powers-that is, India to the east and China to the northeast. This geographic positioning makes the area a nuclear flash point. It is therefore imperative to have commensurate health-care facilities to meet any eventualities. Although Pakistan is trying to improve medical facilities for the people, health-care facilities are already overwhelmed with patients because of the large population of the country. The current study was conducted to evaluate the level of awareness and preparedness of medical responders for nuclear and radiological disasters in public hospitals in the major cities of Pakistan. Methods A detailed questionnaire covering all aspects of the study was designed and discussed with the people most concerned, including health-care workers in the field of medicine, nuclear sciences, and disaster management in Pakistan. It was adopted on the basis of early studies on the subject, with necessary modificatadiological events.

Traumatic brain injury (TBI) is a public health concern that can occur in a range of contexts. Work-related TBI (wrTBI) is particularly concerning. Despite overall work-related injury claims decreasing, the proportion of claims that are wrTBI have increased, suggesting prevention and support of wrTBI requires ongoing attention.

This review aimed to provide updated information on the burden and risk factors of wrTBI among the working adult population.

Medline, Embase, PsycINFO, and Cumulative Index to Nursing and Allied Health Literature (CINAHL) were searched using a combination of TBI, work, and epidemiology text words and medical subject headings. Two reviewers independently assessed articles for inclusion. Meta-analyses were conducted to estimate prevalence and mortality of wrTBI and a narrative synthesis was conducted to provide additional context.

Pooled proportions meta-analyses estimate that 17.9% of TBIs were work-related and 6.3% of work-related injuries resulted in TBI, with 3.6% of wrTBI resulting in death. Populations of wrTBI were predominantly male (76.2%) and were 40.4 years of age, on average. The most commonly reported industries for wrTBI were education and training, healthcare and social assistance, construction, manufacturing, and transportation. Falls, being struck by an object or person, motor vehicle collisions, and assaults were the most commonly reported mechanisms of wrTBI.

A better understanding of the epidemiology of wrTBI can inform prevention and management strategies. This review highlights existing gaps, including a notable lack of sex or gender stratified data, to direct future investigation.

CRD42020169642.

CRD42020169642.