Thus, our inducible CRISPRi ESC line and KI mouse provide versatile and convenient platforms for functional interrogation and high-throughput screens of specific genes and potential regulatory elements in the setting of development or diseases.Children with Congenital Zika Syndrome and microcephaly are at high risk for epilepsy; however, the risk…[Read more]

Unexpectedly, in the cancer microenvironment, dexamethasone response score positively correlates with a subset of innate immune cells. This indicates that dexamethasone potentially correlated with anti-cancer immunity in the cancer microenvironment which may be on the contrary to its systemic effect.

Our systems-level analysis define the…[Read more]

oclopramide appears to be safer and longer acting than neostigmine in the Arabian horse breed. Ultrasonography is a valuable noninvasive tool for the quantification of intestinal contractility. Future studies should consider the use of various dosages of metoclopramide and administration routes and investigate its impact on horses with GI transit…[Read more]

There are concerns regarding the difference between directly recorded and measured entrance skin dose (ESD) and average glandular dose (AGD) in full-field digital mammography (FFDM). The objective of the study was to evaluate the effect of different exposure parameters on ESD and AGD recorded directly and measured from an FFDM unit using a…[Read more]

The method utilises a supervised Support Vector Classification (SVC) algorithm to detect delaminations using temperature data from either the edge of the defect or the centre during a 140 s ramped heating period to 80 °C. An F1 score in the classification of delaminations or no delamination at an overall accuracy of over 99% in both training and…[Read more]

Overall, our work supports the utility to apply personal genomic information for characterizing complex disease phenotypes.Mitochondrial dysfunction and iron (Fe) dyshomeostasis are invoked among the mechanisms contributing to muscle aging, possibly via a detrimental mitochondrial-iron feed-forward loop. We quantified the labile Fe pool, Fe…[Read more]

Background and objectives Polyvascular atherosclerosis is frequent and associated with a high cardiovascular risk, although the mechanisms regulating the atherosclerosis extent to single or multiple arterial territories are still poorly understood. Inflammation regulates atherogenesis and soluble CD40 ligand (sCD40L) is an inflammatory mediator…[Read more]

N in children.

To estimate lifetime prevalence of mental disorders in the Saudi National Mental Health Survey (SNMHS).

The SNMHS is a face-to-face community epidemiological survey in a nationally representative household sample of citizens ages 15-65 in the Kingdom of Saudi Arabia (KSA) (n = 4,004). The World Health Organization (WHO)…[Read more]

Angioedema induced by angiotensin-converting enzyme (ACE) inhibitors is rare; however, once it occurs, it can be potentially life threatening, especially for patients with possible difficult airway. Considering the risk-benefit ratio, we must be careful in administering ACE inhibitor therapy in morbidly obese patients.Mesenchymal stem cells (MSCs)…[Read more]

Additional geopolymerisation from γ irradiation is controlled by the rate-limiting release of Si4+ from the unreacted aluminosilicates and silicates and their rapid incorporation in the geopolymer network. The aqueous leaching of the geopolymer pastes is not affected significantly by γ irradiation. These data reveal the potential for these m…[Read more]

To assess the risk of chronic kidney disease (CKD) associated with tenofovir disoproxil fumarate (TDF) use by baseline DAD CKD risk score.

Adult antiretroviral therapy (ART)-naïve people living with HIV (PLWH) initiating treatment, with estimated glomerular filtration rate (eGFR) ≥60mL/min/1.73m

, were identified in the OPERA co…[Read more]