Additive Manufacturing (AM) or rapid prototyping technologies are presented as one of the best options to produce customized prostheses and implants with high-level requirements in terms of complex geometries, mechanical properties, and short production times. The AM method that has been more investigated to obtain metallic implants for medical and biomedical use is Electron Beam Melting (EBM), which is based on the powder bed fusion technique. One of the most common metals employed to manufacture medical implants is titanium. Although discovered in 1790, titanium and its alloys only started to be used as engineering materials for biomedical prostheses after the 1950s. R788 In the biomedical field, these materials have been mainly employed to facilitate bone adhesion and fixation, as well as for joint replacement surgeries, thanks to their good chemical, mechanical, and biocompatibility properties. Therefore, this study aims to collect relevant and up-to-date information from an exhaustive literature review on EBM and its applications in the medical and biomedical fields. This AM method has become increasingly popular in the manufacturing sector due to its great versatility and geometry control.Fipronil -a broad spectrum phenylpyrazole insecticide has high level of toxicity towards environment. Therefore, an easy and reliable analytical method was developed for residue estimation of fipronil to ensure food and environmental safety. A modified QuEChERS technique was followed for estimation of fipronil (5% SC) in paddy ecosystem using GC-ECD and confirmation by GC-MS/MS. The initial residues (0.168-0.794 μg g-1) of total fipronil i.e., sum of fipronil and its metabolites (viz., desulfinyl and sulfone) in leaf and soil were dissipated following first order kinetics. About 92-96% of fipronil residues were degraded after 15 days with half-life of 3.4-4.1 days and pre-harvest interval of 19.4-25.7 days in plant. Residues were below level of quantification ( 1) for soil ecological health.Healthful tasty high protein, vegetable, gluten-free snacks are needed for all as well as those sensitive to gluten for in between meals and for after school events. Peanut meal a low value farm by-product was used to increase protein content and to add value for growers. Bile acid binding okra with cholesterol lowering potential and jalapeno, turmeric and ginger with healthy phytonutrients were included to increase vegetable consumption. The objective was to have healthy tasty snacks with ≥24% protein content. Gluten-free, whole grain, high protein, Sorghum-Peanut meal-Okra (SPO) and SPO-Jalapeno, SPO-Turmeric root and SPO-Ginger root snacks were sensory evaluated by 73 volunteers. Physical testing of the snacks included water activity, true and bulk density, texture and proximate analyses. Taste and Odor of the SPO and SPO-Jalapeno snacks were similar and significantly (p ≤ 0.05) higher than SPO-Turmeric root and SPO-Ginger root. Acceptability of SPO and SPO-Jalapeno snacks were both 88%; this value is quite desirable. Acceptability of SPO-Turmeric and SPO-Ginger were only 56 and 51% respectively. Turmeric and ginger have been reported with many health benefits; however these snacks were not preferred by the tasters. Water activity (Aw) of the snacks tested was SPO (0.42) less then SPO-Turmeric (0.52) less then SPO-Jalapeno (0.54) less then SPO-Ginger (0.62). Water activity indicates that all the snacks were crispy and had longer shelf life. Expansion of these snacks was SPO-Ginger root 84%, SPO-Turmeric root 76%, SPO-Jalapeno 42% and SPO only 14%. Data suggest snacks containing spices were fluffy and would give good presentation in packaging. The objective of attaining protein level was clearly attained, as values ranged 24-26%. These snacks are easy to make in house kitchens or by food companies. These healthy snacks offer a gluten-free, high protein, tasty choice for all, including vegetarians and individuals hypersensitive to gluten.Congenital myasthenia syndrome (CMS) is a group of heterogeneous diseases affecting the neuromuscular endplate. CMS has a considerably different phenotypic presentations, with the onset time ranging from early infancy to late adulthood. Here, we report a case of a CMS due to a new DOK7 mutation in a 28-year-old man and two of his sisters, who have a pure limb-girdle weakness. DOK7 CMS has a varying presentation. Typically, the onset occurs in childhood with ptosis, bulbar symptoms, difficulty walking, weakness, and gait abnormality. This case sheds light on a novel DOK7 gene mutation with a unique presentation of CMS and provides insight into its unique phenotypic presentation.The purpose of this work has been to analyze, from a structural and functional approach, the families at risk or unprotected by the Family Treatment Teams, inserted in the Public System of Social Services. For this purpose, qualitative research methods and techniques have been used on 26 interdisciplinary reports generated in the most representative cases of family intervention. Significant results have been obtained describing family structures, life-cycle adaptation, pattern repetition across generations, life events and family functioning, and linked patterns. The data reveal that these are families with common problems related mainly to the behaviour of minors and the coverage of basic needs. Negligence is the central element in this type of families as well as the maladjustment to the life cycle of the family system. All this from patterns of repetition linking dysfunctional.This article presents socio-economic, energetic and CO2 emissions’ impact by considering a large-scale integrated plant to treat Municipal Solid Waste (MSW) in the Metropolitan Region of São Paulo (MRSP); the most important Brazilian macro-region. As an alternative to landfills, this plant offers a source of renewable energy and a good assessment of benefits the circular economy provides. Based on the most recent interregional economic transactions data, the proposed Input-Output model has shown reductions in the local energy demand (-0.31%), carbon emissions (-3.40%). On the other hand, it has suggested gains in the GDP (+0.21%) and formal job positions (+0.08% or 10.6k) when recyclables are introduced massively in the economy.