Adaptive backstepping quantized control for any form of unknown nonlinear methods.

Conclusiones Las características del entorno comunal en el cual se desarrollan los niños/as podrían aumentar el riesgo de sobrepeso y obesidad, principalmente las características relacionadas con el nivel socioeconómico; las tasas de denuncias muestran en cambio, una relación inversa con estas condiciones nutricionales.in English, Spanish Este breve documento se centra en el papel de los modelos matemáticos para analizar el impacto de las pandemias en los recursos de salud y las diferentes trade-off que pueden estar presente. Existe una gran cantidad de literatura que sugiere que los modelos matemáticos pueden ser útiles para estimar cuánto equipo e infraestructura adicionales pueden ser necesarios para mitigar un aumento en la demanda de servicios de salud durante un brote a gran escala de una enfermedad infecciosa. Comento sobre el papel crucial de estos modelos con un enfoque especial en sus fortalezas y limitaciones.in English, Spanish Introducción La toma de decisiones es uno de los componentes más importantes dentro de la vida de las personas. En ella intervienen factores cognitivos, los cuales se encargan de procesar los estímulos presentes en la tarea, recordar experiencias pasadas y valorar las posibles consecuencias que pueden tener las decisiones emocionales. Hasta ahora no se encuentran en Ecuador estudios de esta naturaleza que se hayan realizado en este contexto, por lo que esta investigación busca establecer características propias de la población ecuatoriana. Con los resultados obtenidos se pretende contar con una aproximación a la forma de tomar decisiones de esta población en su vida cotidiana. Objetivo Relacionar la toma de decisiones con la regulación del comportamiento y la metacognición en una muestra de hombres ecuatorianos. Métodos Diseño cuasi experimental. Participaron 33 sujetos de sexo masculino de la población general. La toma de decisiones fue evaluada a través de la tarea experimental del Iowa nculado a decisiones riesgosas y no riesgosas, y su asociación con diferentes funciones ejecutivas a través de la aplicación de un cuestionario.BACKGROUND Patients with end-stage renal disease undergoing long-term maintenance hemodialysis are more likely than the general population to exhibit primary hypothyroidism. Only a few cases of isolated adrenocorticotropic hormone deficiency (IAD) among hemodialysis patients have been reported. We herein report an unusual case of a patient undergoing long-term hemodialysis who exhibited both IAD and primary hypothyroidism. CASE REPORT A 82-year-old male with end-stage renal disease secondary to immunoglobulin A nephropathy, undergoing hemodialysis for 20 years, was found to have primary hypothyroidism without obvious symptoms and consequently began thyroid hormone replacement therapy with oral levothyroxine. At 84 years of age, he developed anorexia, fatigue, and lethargy. A systemic workup using computed tomography and gastrointestinal endoscopy detected no abnormalities. He did not exhibit electrolyte imbalances, such as hyponatremia or hyperkalemia, and had normal morning blood levels of cortisol and adrenocorticotropic hormone. However, he exhibited hypoglycemic coma 4 months later. Detailed endocrinological examinations using dynamic function tests indicated IAD. Androgen Receptor inhibition After commencement of corticosteroid replacement therapy, his symptoms resolved without complications. CONCLUSIONS To our knowledge, this is the first report of a hemodialysis patient with both IAD and primary hypothyroidism. This case highlights the importance of regular assessments of thyroid function for primary hypothyroidism in hemodialysis patients, even when they are asymptomatic. Furthermore, timely dynamic endocrine testing of hypothalamic-pituitary-adrenal function is needed to diagnose possible IAD in hemodialysis patients with symptoms suggestive of adrenal insufficiency, even in the absence of abnormal laboratory findings such as electrolyte imbalances or low morning blood levels of cortisol or adrenocorticotropic hormone.BACKGROUND The treatment of cancer is still unable to meet the needs of patients and remains a huge challenge. This study investigated the immune response and anti-cancer effect of silencing STAT3 combined with the use of anti-PD-L1 antibody. MATERIAL AND METHODS Transfected CT26.WT cells were used to subcutaneously inoculate C57B/L6 mice, which were subsequently injected with anti-PD-L1 antibody. Treated mice were examined for tumor formation and inflammation using HE staining. Tumors were investigated for apoptosis using the TUNEL assay. The expression of STAT3, PD-L1, and C-met was studied immunohistochemistrially and by using PCR and Western blot analysis. RESULTS Four weeks after inoculation, tumors were observed in the inoculated mice. HE staining showed obvious inflammation in mice injected with cells that were silenced for STAT3 and injected with PD-L1 antibody. TUNEL assay showed low level of apoptosis in mice injected with cells silenced for STAT3 or injected with PD-L1 antibody, and higher level of apoptosis following combined treatment of STAT3 silencing and PD-L1 antibody injection. Immunohistochemistry, PCR, and Western blot analyses revealed that the expression of C-met, PD-L1, and STAT3 was significantly reduced in tumors following the combined treatment. Compared with treatment of STAT3 silencing or PD-L1 antibody injection, the combined treatment enhanced apoptosis. CONCLUSIONS Silencing STAT3 and PD-L1 antibody injection in combination increased apoptosis in tumor cells and thus offers better anti-cancer activity.Diabetic retinopathy (DR) is the leading cause of blindness in working-age adults. Vascular pericyte degeneration is the predominant clinical manifestation of DR, yet the mechanism governing pericyte degeneration is poorly understood. Circular RNAs (circRNAs) play important roles in multiple biological processes and disease progression. Androgen Receptor inhibition Here, we investigated the role of circRNA in pericyte biology and diabetes-induced retinal vascular dysfunction. cZNF532 expression was upregulated in pericytes under diabetic stress, in the retinal vessels of a diabetic murine model, and in the vitreous humor of diabetic patients. cZNF532 silencing reduced the viability, proliferation, and differentiation of pericytes and suppressed the recruitment of pericytes toward endothelial cells in vitro. cZNF532 regulated pericyte biology by acting as a miR-29a-3p sponge and inducing increased expression of NG2, LOXL2, and CDK2. Knockdown of cZNF532 or overexpression of miR-29a-3p aggravated streptozotocin-induced retinal pericyte degeneration and vascular dysfunction.