There is no significant difference observed between two groups for three studied polymorphisms. None of the polymorphisms deviated significantly from the Hardy Weinberg equilibrium, suggesting that the distribution in our subjects was representative of the actual population. The level of cytokines is guarded by various parameters, which are essential for a successful pregnancy. It is very complicated to predict the effect on endometrium and corresponding pregnancy rates due to increased progesterone. BACKGROUND AND OBJECTIVE Mobile applications could be effectively used for dietary intake assessment, physical activity monitoring, behavior improvement, and nutrition education. The aim of this review is to determine the effectiveness of mobile applications in improving nutrition behaviors through a systematic review of literature. METHODS The review protocol was registered with PROSPERO registration number CRD42018118809, and followed PRISMA guidelines. We involved original articles including mobile electronic devices for improving dietary intake, physical activity, and weight management in adult populations in this review. Data were retrieved from January 2010 to December 2018 with PubMed, Web of Science, Excerpta Medica Database (Embase), and Cumulative Index to Nursing and Allied Health Literature (CINAHL) as data sources. Authors individually screened the titles and abstracts, then full articles in order to obtain papers that met inclusion criteria. RESULTS The database search yielded 2962 records. Afte, perhaps with multiple intervention arms, are required to compare across programs the elements that are essential for health benefits observed. V.Findings are inconsistent in studies for impacts of outdoor air pollutants on airway health in childhood. In this paper, we collected data regarding airway and allergic symptoms in the past year before a survey in 13,335 preschoolers from a cross-sectional study. Daily averaged concentrations of ambient sulphur dioxide (SO2), nitrogen dioxide (NO2), and particulate matter with an aerodynamic diameter ≤10 μm (PM10) in the past year before the survey were collected in the kindergarten-located district. We investigated associations of 12-month average concentrations of these pollutants with childhood airway and allergic symptoms. In the two-level (district-child) logistic regression analyses, exposure to higher level of NO2 and of PM10 increased odds of wheeze symptoms (adjusted OR, 95%CI 1.03, 1.01-1.05 for per 3.0 μg/m3 increase in NO2; 1.22, 1.09-1.39 for per 7.6 μg/m3 increase in PM10), wheeze with a cold (1.03, 1.01-1.06; 1.22, 1.08-1.39), dry cough during night (1.05, 1.03-1.08; 1.23, 1.09-1.40), rhinitis symptoms (1.11, 1.08-1.13; 1.32, 1.07-1.63), rhinitis on pet (1.11, 1.05-1.18; 1.37, 0.95-1.98) and pollen (1.12, 1.03-1.21; 1.23, 0.84-1.82) exposure, eczema symptoms (1.09, 1.05-1.12; 1.22, 0.98-1.52), and lack of sleep due to eczema (1.12, 1.07-1.18; 1.58, 1.25-1.98). Exposures to NO2 and PM10 were also significantly and positively associated with the accumulative score of airway symptoms. Similar positive associations were found of NO2 and of PM10 with the individual symptoms and symptom scores among preschoolers from different kindergarten-located district. These results indicate that ambient NO2 and PM10 likely are risk factors for airway and allergic symptoms in childhood in Shanghai, China. Lead (Pb) and cadmium (Cd) are common heavy metals in the environment, exerting detrimental effects on central nervous system. RIN1 Although increasing evidence demonstrated the Pb and Cd-induced neurotoxicity, the exact epigenetic mechanisms induced by combined exposure (co-exposure) of Pb and Cd are still unclear. In this study, the neurotoxicity of individual exposure and co-exposure to Pb and Cd in vivo (150 ppm and 5 ppm respectively) and in vitro (10 μM and 0.1 μM respectively) was investigated. The results showed that neurite outgrowth was inhibited by either individual or combined exposure to Pb/Cd, whereas the co-exposure aggravated the inhibitory effect in PC12 cells. The results of Morris Water Maze (MWM), Y maze and Golgi-Cox staining showed that either Pb or Cd alone exposure damaged the ability of learning and memory and decreased the dendritic spine density in both the hippocampal CA1 and DG area of Sprague—Dawley (SD) rats, and that the co-exposure aggravated the damages. Subsequently, histone deacetylase (HDAC) 2 was significantly increased in both hippocampal tissues and PC12 cells co-exposed to Pb and Cd, and the treatment of trichostatin A (TSA) and HDAC2-knocking down construct (shHDAC2) could markedly prevent neurite outgrowth impairment in PC12 cells. In summary, HDAC2 plays essential regulatory roles in neurotoxicity induced by the co-exposure to Pb and Cd, providing a potential molecular target for neurological intervention. Hydrogen peroxide (H2O2) acts as a significant regulatory component interrelated with signal transduction in plants. The positive role of H2O2 in plants subjected to myriad of abiotic factors has led us to comprehend that it is not only a free radical, generated as a product of oxidative stress, but also helpful in the maintenance of cellular homeostasis in crop plants. Studies over the last two centuries has indicated that H2O2 is a key molecule which regulate photosynthesis, stomatal movement, pollen growth, fruit and flower development and leaf senescence. Exogenously-sourced H2O2 at nanomolar levels functions as a signalling molecule, facilitates seed germination, chlorophyll content, stomatal opening, and delays senescence, while at elevated levels, it triggers oxidative burst to organic molecules, which could lead to cell death. Furthermore, H2O2 is also known to interplay synergistically or antagonistically with other plant growth regulators such as auxins, gibberellins, cytokinins, abscisic acid, jasmonic acid, ethylene and salicylic acid, nitric oxide and Ca2+ (as signalling molecules), and brassinosteroids (steroidal PGRs) under myriad of environmental stresses and thus, mediate plant growth and development and reactions to abiotic factors. The purpose of this review is to specify accessible knowledge on the role and dynamic mechanisms of H2O2 in mediating growth responses and plant resilience to HM stresses, and its crosstalk with other significant PGRs in controlling various processes. More recently, signal transduction by mitogen activated protein kinases and other transcription factors which attenuate HM stresses in plants have also been dissected.