However, it is important to realise that while the majority of identified barriers may be perceived or mitigated some may be absolute and if identified early in device development further investment should be carefully considered.

Findings from this study demonstrate the complex motivations of stakeholders in the adoption of POCT. Most themes…[Read more]

The main clinical manifestations of patients were pain (5/7) and fever (3/7). In immunohistochemistry, all patients’ samples were CD99 positive. All patients died in our follow-up, with an average overall survival (OS) of 12.09 months (1.90-26.77 months).

As a rare renal tumor, renal PNET has a propensity to occur in young males. Most…[Read more]

Moreover, among the participants, female gender, age, fewer years from HIV diagnosis and not being aware of their own viremia were associated to a higher risk of negative psychological outcomes. Almost half of our PLWH sample experienced significant levels of distress related to the COVID-19 pandemic. Women, elderly patients and those with recent…[Read more]

Tumors are characterized by extracellular matrix (ECM) deposition, remodeling, and cross-linking that drive fibrosis to stiffen the stroma and promote malignancy. The stiffened stroma enhances tumor cell growth, survival and migration and drives a mesenchymal transition. A stiff ECM also induces angiogenesis, hypoxia and compromises anti-tumor…[Read more]

ssociated with significant improvement in the metabolic profile and in subclinical myocardial function. Early improvement in subclinical myocardial function following bariatric surgery was related to a greater mobilization of visceral fat depot, linked to global fat dysfunction and cardiometabolic morbidity.

Bariatric surgery was associated…[Read more]

BACKGROUND The National Early Warning Score 2 (NEWS2) scores can help identify clinical deterioration. OBJECTIVE To assess the predictive capacity of the NEWS2 at prehospital level for the detection of early mortality in the hospital. METHODS Prospective multicenter cohort study, in which we compiled a database of observed vital signs between…[Read more]

Meanwhile, EAT and interukin-1β (r = 0.530, p less then 0.05), monocyte chemotactic protein-1 (r = 0.524, p less then 0.05), triglyceride (r = 0.493, p less then 0.05) and sedentary behavior (r = 0.459, p less then 0.05) presented a positive correlation, while EAT and lean body mass (r = -0.453, p less then 0.05) showed a negative correlation. Bavd…[Read more]

Participants (N = 24) demonstrated adequate retention (75.0%), adherence to the intervention (M = 5.3 of 6 sessions), and satisfaction with the intervention. Participants demonstrated significant improvements in transition readiness (p = .001), self-efficacy (p = .002), medication adherence (p = .02), and health literacy (p = .05).

A medic…[Read more]

The frequency of rheumatoid vasculitis has decreased over the last decade. CONCLUSION The clinical manifestations of rheumatoid vasculitis were similar to previous studies. The frequency of rheumatoid vasculitis seems to decrease. However, the clinical picture and severity remains invariable. L.U.INTRODUCTION The aim of this study was to identify…[Read more]

The results of repeated kidney biopsies confirmed by LV-SEM suggested the possibility of a state unrelated to LN.Oliguric acute kidney injury due to traumatic rhabdomyolysis can be potentially lethal if the proper medical therapy combined with extracorporeal detoxification is not performed. Different extracorporeal techniques are available to…[Read more]

Alternative metrics are emerging scores to assess the impact of research beyond the academic environment.

To analyse whether a correlation exists between manuscript characteristics and alternative citation metrics.

This bibliometric analysis included original articles published in the five journals with the highest impact factors…[Read more]

The glioma stem cells (GSCs) are a small fraction of cancer cells which play essential roles in tumor initiation, angiogenesis, and drug resistance in glioblastoma (GBM), the most prevalent and devastating primary brain tumor. The presence of GSCs makes the GBM very refractory to most of individual targeted agents, so high-throughput screening…[Read more]