Median follow-up was 8.0 years (1.8 months-17.0 years). DOW, dosing schedule and TCD were not associated with any outcomes in univariable or multivariable regression models. There was no statistically significant difference in creatinine or association with TCD in split-HD vs bolus-HD. There was no statistically significant association between DOW and outcomes, suggesting that cisplatin could be administered any day. Split-HD had no observed differences in outcomes, renal toxicity or TCD compared to bolus-HD cisplatin. Our data suggest that there is some flexibility of when and how to give HD cisplatin compared to clinical trial mandates.

To assess the effect of an online psychoeducational program on international students’ abilities to cope with and adapt to stress.

The study had an experimental design with a pre- and posttest and a control group. The sample consisted of 60 participants randomly assigned to the control and experimental groups.

The psychoeducational stress management program was effective in decreasing the stress levels and improving the capacity to cope with the participants in the experimental group.

The study provides information to psychiatric nurses and student support services about how to assist international nursing students in coping with stress.

The study provides information to psychiatric nurses and student support services about how to assist international nursing students in coping with stress.

Caffeine is an antagonist of the adenosine pathway, which is involved in regulation of breathing. Extracellular concentrations of adenosine are increased in the immediate aftermath of a seizure. Seizure-related overstimulation of adenosine receptors might promote peri-ictal apnea. However, the relation between caffeine consumption and risk of seizure-related respiratory dysfunction in patients with drug-resistant focal epilepsy remains unknown.

We performed a cross-sectional analysis of data collected in patients included in the SAVE study in Lyon’s epilepsy monitoring unit at the Adult Epilepsy Department of the Lyon University Hospital between February 2016 and October 2018. The video-electroencephalographic recordings of 156 patients with drug-resistant focal epilepsy included in the study were reviewed to identify those with ≥1 focal seizure (FS), valid pulse oximetry (SpO

) measurement, and information about usual coffee consumption. This latter was collected at inclusion using a standardized self-ctor for seizure-related respiratory dysfunction, with a dose-dependent effect.

Coffee consumption may be a protective factor for seizure-related respiratory dysfunction, with a dose-dependent effect.The primary aim of this study was to conduct a cross-cultural comparison of the level of critical thinking of Danish and Spanish psychology students (N = 788) attending innately different bachelor-level courses; personality psychology and introductory statistics/research methods. Several instruments are available for the assessment of critical thinking (CTh), but most are, however, unsuitable for use in large surveys with many constructs, due to length or single-person administration formats. One brief and much-used scale is the CTh scale in the Motivated Strategies for Learning Questionnaire (MSLQ), used in this study. To ensure unbiased comparisons across countries and courses, our secondary aim was to investigate the content validity, as well as the psychometric properties, of the CTh scale to ensure the most accurate and unbiased comparison. For this purpose, Rasch and graphical loglinear Rasch models were used. After reducing the number of items due to content validity issues, the CTh scale fitted Rasch models within each national sample, and was measurement invariant relative to age group, gender, course and university. In the cross-cultural item analysis, two items functioned differentially relative to nationality, and the scale fitted a graphical loglinear Rasch model. CTh scores related to introductory statistics/research methods courses differed significantly from scores related to personality psychology, for Danish students only.Resolvin D1 (RvD1) is an endogenous lipid mediator that originated from docosahexaenoic acid that stimulates a bimodal mechanism in the anti-inflammatory activity in addition to regulation of the inflammatory reaction. The study aimed at assessing the tissue level of RvD1 in psoriasis to study its role in the etiopathogenesis of psoriasis, studying the action of NB-UVB on the level of resolvin D1 in psoriasis, and raising the possibility of using resolvin D1 as a new therapy for psoriasis in the future. This case-control study included 20 psoriasis patients and 20 healthy controls. Patients took narrowband ultraviolet B (NB-UVB) for 36 sessions. Skin biopsies were taken before and after treatment from patients and from controls to assess the expression of RvD1 by a quantitative real-time polymerase chain reaction. this website Our findings revealed a statistically significant difference (P  less then  .001) between psoriasis patients (either before or after treatment) and controls with lower levels of RvD1 in psoriasis patients. On comparing the RvD1 levels in psoriasis patients before and after treatment, a statistically significant increase was detected after treatment (P  less then  .001). Tissue RvD1 levels in psoriasis patients were lower than healthy controls and increased after NB-UVB treatment in psoriasis patients. Thus, it is suggested that RvD1 might have a role in the etiopathogenesis of psoriasis. Moreover, the significantly up-regulated tissue levels of RvD1 in patients after treatment with NB-UVB highlighted a novel mechanism of phototherapy-mediated response in psoriasis by up-regulating RvD1 level.Global demands for energy-efficient heating and cooling systems coupled with rising commitments toward net zero emissions is resulting in wide deployment of shallow geothermal systems, typically installed to a depth of 100 to 200 m, and in the continued growth of the global ground source heat pump (GSHP) market. Ground coupled heat pump (GCHP) systems take up to 85% of the global GSHP market. With increasing deployment of GCHP systems in urban areas coping with limited regulations, there is growing potential and risk for these systems to impact the subsurface thermal regime and to interact with each other or with nearby heat-sensitive subsurface infrastructure. In this paper, we present three numerical modeling case studies, from the UK and Canada, which examine GCHP systems’ response to perturbation of the wider hydrogeological and thermal regimes. The studies demonstrate how GCHP systems can be impacted by external influences and perturbations arising from subsurface activities that change the thermal and hydraulic regimes in the area surrounding these systems.