Reductions in risk levels were maintained over time (at least 1 level OR 5.39, 95% CI 3.43, 8.47; at least 2 levels OR 9.30, 95% CI 6.14, 14.07). Reductions were associated with reduced consequences of drinking and number of AUD symptoms, and minor, but statistically significant, improvements in quality of life.

Maintaining reductions in WHO risk levels appears achievable for older adults seeking treatment for AUD. The small reduction of AUD symptoms and improvement of quality of life indicates that these reductions may not be adequate as the only treatment goal.

Maintaining reductions in WHO risk levels appears achievable for older adults seeking treatment for AUD. The small reduction of AUD symptoms and improvement of quality of life indicates that these reductions may not be adequate as the only treatment goal.The role of antigen-presenting cells in the skin immune system, in particular Langerhans cells and dendritic cells, has not been well defined. We recently published a study in ‘Immunology’ where we reported that the loss of langerin-positive cells in the skin accelerated wound repair in the Lang-DTR mouse. The study published here by Li, et al. reports delayed wound closure following depletion of CD11c-positive cells in the CD11c-DTR mouse. In this commentary, we attribute the differences between these results to several factors that differ between the studies including the depletion of different cell populations; differences in the age and the sex of mice; differences in antibiotic use between the studies; and differences in the location of the biopsies that were taken. Here, we describe the impact of these differences on wound healing and conclude that further standardization of the wound model, and further characterization of the specific cells that are depleted in these mice, is necessary to better understand how antigen-presenting cells contribute to wound healing.Urban forest patches can provide critical ecosystem services and their ability to regenerate native tree species is critical to their sustainability. Little is known about native tree seedling establishment and physiological function in urban ecosystems. This growth chamber study examined the effects of urban soil and air temperatures on white oak (Quercus alba L.) germination, seedling growth, and leaf-level physiology. A split-plot design tested effects of field collected soils from urban and reference forest sites in Baltimore, Maryland, and warm (urban) versus cool (rural) growth chamber temperature regimes. Seedlings were harvested at the end of the 23-week experiment to assess foliar chemistry and biomass allocation. Seed germination was unaffected by treatments and was high in both soil types and temperature regimes. Urban soils supported significantly higher total seedling biomass and had a significant effect on leaf-level physiological parameters, with seedlings grown in urban soils having greater Anet , Vcmax , ETRmax , Jmax , PNUE, gs , Anet /Rd , and PIabs (an integrated chlorophyll fluorescence parameter). PIabs measurements taken throughout the experiment revealed a significant time × temperature interaction effect. Baltimore urban forest patch soils were higher in nutrients than reference soils, but also higher in heavy metals. Despite higher levels of heavy metals, these results demonstrate that urban forest patch soils are able to support robust white oak seedling growth and enhanced seedling physiological parameters. However, interactions with temperature suggest that warming air temperatures may cause seedling stress and reduced growth.The above article, published online on 05 September 2017 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the authors, the journal’s Editor-in-Chief, Dr. Shinya Murakami, and John Wiley & Sons A/S. The retraction has been agreed as the Institutional Animal Care and Use Committee (IACUC) approval for the experimental peri-implantitis procedure used in this article was still pending at the time that the procedure was performed. The IACUC approval for the peri-implantitis procedure was received in 2017 after the article had been submitted. Although all the research design, methods, and results are valid, IACUC approval was not received at the time the research was performed, which is a requirement for all research submitted to the journal. The authors have agreed to retract the article.Most women with breast cancer can become pregnant and give birth while undergoing radiation therapy and breastfeeding is generally not contraindicated. The induction of long-lived reactive species in proteins, such as casein by X-ray radiation and DNA damage to unexposed organisms, has been shown when ingesting irradiated cheese. To determine whether exposing lactating rats to X-rays increases the number of micronucleated erythrocytes (MNEs) in peripheral blood of their unexposed or breastfeeding rat pups, 15 female Wistar rats were divided into three groups Negative control; Experimental group exposed to X-rays, and group exposed to X-rays plus vitamin C. The mothers of groups 2 and 3 were irradiated for three consecutive days after giving birth, returning them to their respective cages each time to continue lactation. A blood sample was taken from the mothers and pups at 0, 24, and 48 hr. Blood smears were stained with acridine orange to analyze MNEs. In mother rats, the frequency of micronucleated polychromatic erythrocytes (MNPCEs) increased significantly at 24 and 48 hr in both study groups exposed to radiation. Likewise, in rat pups the MNPCE and MNE frequencies increased in both groups with radiation and radiation plus vitamin C at 24 and 48 hr, and a protection from vitamin C was observed. In conclusion, the genotoxic damage produced in rat pups that were lactated by mothers irradiated with X-rays is possibly due to the effect of long-lived reactive species that were formed in the breast milk of female Wistar rats during the irradiation process.A variety of sucrose replacers (SRs) are increasing in popularity for reducing sucrose usage in low moisture baked goods (cookies, biscuits, etc.). The goal of this study was to link SR physicochemical properties to their observed effects on starch thermal properties, including results from differential scanning calorimetry, rapid viscoanalysis, particle size analysis, and model wire-cut cookie baking performance. The 12 SRs examined in this study were Truvia, Splenda, Swerve, coconut palm sugar, Monk Fruit, erythritol, Benefiber, Miralax, blue agave syrup, yacon syrup, Sukrín Fiber Gold Syrup, and date syrup. The onset gelatinization temperature (Tgel ) of wheat starch increased significantly (P 10) decreased paste viscosity (peak and final), decreased granule swelling, and increased Tgel compared to the control (water). The smaller SRs (DP less then 10) increased both paste viscosity (peak and final) and granule swelling, unlike the larger SRs, and did not increase Tgel as much as larger SRs. selleck chemicals llc The SRs which performed similar to sucrose in model cookie baking (fracturability, spread, color, etc.