OBJECTIVE Juvenile dermatomyositis (JDM) is a rare disease in children that is treatable, but patients may suffer from long-term effects of the disease. Clinical trials are needed to find better treatments for affected patients. Among validated tools for evaluating disease activity clinically is the disease activity score (DAS), but it is not…[Read more]

Tendinosis is a chronic degenerative condition. Current research suggests both percutaneous needle tenotomy (PNT) and leukocyte-rich platelet-rich plasma (LR-PRP) may be effective treatments for chronic tendinosis, but no studies have assessed the effectiveness of PNT alone versus PNT with intratendinous LR-PRP for multiple tendon types in a…[Read more]

The findings add to the growing evidence that self-guided online interventions are feasible and potentially efficacious in treating female sexual dysfunction.Dual-energy X-ray absorptiometry (DXA)-derived appendicular lean mass/height2 (ALM/ht2 ) is the most commonly used estimate of muscle mass in the assessment of sarcopenia, but its predictive…[Read more]

These results demonstrate that accurate future predictions of the case load in a given country can be made using this very simple model.

Staff working in mental health services provide care for individuals with a variety of difficulties, which can pose treatment challenges. Perceived lack of progress in patients can engender uncomfortable…[Read more]

Constipation is one of the most important nonmotor symptoms in Parkinson’s disease (PD) patients, and constipation of different severities is closely related to the pathogenesis of PD. PD with constipation (PDC) is considered a unique type of constipation, but its mechanism of formation and factors affecting its severity have been less reported.…[Read more]

Considering the recent COVID-19 pandemic, we recognised a lack of synthesis amongst the available literature pertaining to the intersections of homelessness and pandemic response and planning. Therefore, the purpose of this review was to identify relevant peer-reviewed literature in this area to thematically produce evidence-based recommendations…[Read more]

48, 95% CI1.04-19.34). Vitamin D status at birth or six months was not associated with subsequent pneumonia incidence, but greater maternal sun exposure during pregnancy was associated with a trend to less frequent ARI and pneumonia in infants.

ARI, pneumonia, and vitamin D deficiency at birth were common in Indonesian infants. Minimising…[Read more]

A food waste treating system was proposed in this study by combining biochar-assisted high-solid anaerobic digestion and subsequent steam gasification of the digestate. The effect of solid level, biochar dosage in anaerobic digestion on the properties of biogas, syngas, and final biochar products were investigated. Results showed that at a high…[Read more]

Somatic expansion of the CAG repeat tract that causes Huntington’s disease (HD) is thought to contribute to the rate of disease pathogenesis. Therefore, factors influencing repeat expansion are potential therapeutic targets. Genes in the DNA mismatch repair pathway are critical drivers of somatic expansion in HD mouse models. Here, we have tested,…[Read more]

Protective factors included clinicians’ knowledge and confidence, preventive medical approach, risk and needs assessment, patient-clinician communication, relationship quality, psychosocial support, symptom management, accessibility of psychosexual care, and self-efficacy in the rediscovery of sexuality.

Despite the high incidence and…[Read more]

Integration of transcriptomics and metabolomics data can provide detailed information for better understanding the molecular mechanisms underlying salt tolerance in rice. In the present study, we report a comprehensive analysis of the transcriptome and metabolome of rice overexpressing the OsDRAP1 gene, which encodes an ERF transcription factor…[Read more]