to report four novel TUBB4A mutations leading to laryngeal and cervical dystonia with frequent generalization.

DYT-TUBB4A, formerly known as DYT4, has only been described in one large family and two individual cases. The clinical picture highlighted in the original family comprises laryngeal and cervical dystonia extending to generalized…[Read more]

Mesentericorenocaval portosystemic shunt morphology has not been previously reported in the cat and should be considered as a differential diagnosis for cats presenting with peripartum onset of malaise, ptyalism or ataxia.

An 8-year-old spayed female domestic shorthair cat was presented for a recheck evaluation of hypertrophic cardiomyopathy…[Read more]

Our findings suggest that DENV-2 was the major serotype causing the 2019 massive outbreak in Nepal. This information will help in disease control programs to understand the molecular epidemiology and its changing trend.

Our findings suggest that DENV-2 was the major serotype causing the 2019 massive outbreak in Nepal. This information will help…[Read more]

0001). Total radiation dose (419.3 ± 317.9 vs 998.3 ± 673 mGy, p less then 0.0001) and contrast administration (83.2 ± 22.3 mL vs 191.6 ± 33.4 mL, p less then 0.0001) were significantly lower in control group. There was no significant difference in 2-year success rate, 35.2% of patients had AF recurrence in the 3DRA group and 30.3% in the con…[Read more]

Total SLE disease activity index 2000 score decreased by ≥4 at EOT in 7 of 17 subjects.

Amiselimod was generally well tolerated. HDAC inhibitor While no serious AEs or infectious AEs led to discontinuation, low lymphocyte counts of <200/μl were observed as a laboratory abnormality. Our findings suggest the potential efficacy of am…[Read more]

ated with the height standard deviation score (r=0.255; p less then 0.05), but was not correlated with serum MKRN3 level or the others. Conclusion Although serum NPTX1 level was independent of serum MKRN3 level, the possibility they might be involved in the progression of puberty or CPP remains. Further research is needed to determine their role…[Read more]

Indoor pollutants can have short- and long-term health effects, especially if exposure occurs during prenatal life or early childhood. read more This study describe the perceptions, knowledge, and practices of adults concerning indoor environmental pollution. Adults of 18 to 45 years of age were recruited in the department of Ille-et-Vilaine…[Read more]

elegans in its natural environment.Mental health professionals have a responsibility to ensure the best possible quality of care. Family is strongly involved in the patient’s everyday life. The aim of this study was to investigate the relationship between health care professionals’ perception of the quality of care, attitudes of family involvement…[Read more]

Hepatitis E is an infectious disease of the liver caused by the hepatitis E virus (HEV). Immunocompromised patients present a particular risk group, as chronification of hepatitis E leading to life-threatening cirrhosis occurs when these patients are infected. Therefore, this study aims to estimate and compare the anti-HEV seroprevalence and the…[Read more]

Serum intact parathyroid hormone (iPTH) levels are high or high normal in patients with parathyroid adenoma. Rarely these patients can have normal or low serum iPTH values. With sandwich immunometric assays, an exceptionally high serum iPTH level can lead to falsely low measurement due to the ‘hook effect’. Here, we describe the case of a…[Read more]

The apparent fiber density and complexity metric showed relatively minor differences when only q-space undersampling was used, but deteriorate when k-space undersampling was applied. Likewise, the tract density weighted image showed good results when only q-space undersampling was applied using 15 directions or more, but information was lost when…[Read more]

However, none of the existing methods was suitable for Geoalkalibacter subterraneus, Geobacter pickeringii, and Mus musculus, thereby limiting their practical applicability. Model transferability to five species and non-transferability to three species are also discussed. The presented evaluation will assist researchers in selecting appropriate…[Read more]

In addition, MHO seems to be a transient phenotype further justifying therapeutic weight loss attempts even in this subgroup which might not benefit from reducing body weight to the same extent as patients with unhealthy obesity. MHO represents a model to study mechanisms linking obesity to cardiometabolic complications. MHO should not be…[Read more]