Results highlight the need for health practitioners to recognize the role of audience involvement in celebrity health events and to better assess how to harness these opportunities to promote healthy behaviors.

Efforts to incorporate evidence-informed practice within child welfare have been increasingly adopted to promote positive outcomes for youth. We established partnerships with three child welfare agencies to develop, implement, and evaluate a training curriculum delivered to senior managers and supervisors. The training focused on the use of data from an Ontario performance measure system. Despite its mandatory use, challenges remain in the applied use of the data to organizational governance and planning.

This pilot study examined senior managers’ and supervisors’ perspectives of the training using a mixed-methods design consisting of a training feedback questionnaire and post-training focus groups.

Results indicated that participants responded positively to the training content, delivery, and facilitators. Participants identified that it was helpful to learn about applied data and evidence-informed practice.

These findings highlight the importance of ongoing training initiatives within child welfare to promote an organizational culture supportive of evidence-informed practice.

These findings highlight the importance of ongoing training initiatives within child welfare to promote an organizational culture supportive of evidence-informed practice.Recent studies suggest the use of topical nitroglycerin (NTG) application in systemic sclerosis (SSc)-associated Raynaud phenomenon (RP). With the current study, we aimed to characterize for the first time the microvascular response to a NTG patch (Trinipatch® 5 mg/24 h) applied to the hand dorsum in patients with SSc using Laser Doppler imaging (LDI) at baseline and following a cold challenge. The study included 21 patients with SSc and 13 controls. Blood flow was evaluated by LDI at the level of the fingertips and metacarpus. Microvascular morphology was evaluated by nailfold capillaroscopy (NC). LDI revealed decreased fingertip baseline perfusion and a stronger vasoconstrictor response to a cold challenge in patients with SSc versus control. Metacarpal application of a NTG patch led to an increase in blood flow and hand temperature in patients with SSc. Furthermore, NTG administration led to a faster reperfusion after cold challenge. Correlation analyses revealed that the magnitude of the vasodilatory response was inversely related to baseline fingertip perfusion and hand temperature, but unrelated to the number of capillaries/mm assessed using NC. In conclusion, we provide evidence of a vasodilatory reaction following NTG patch application in patients with SSc using LDI and a protective effect against cold challenge. The magnitude of the response to NTG was related to functional, but not structural features. Our results support a further evaluation of the NTG patch as a possible therapeutic agent in SSc-associated RP.Caring for older adults is viewed as a low prestigious profession and a less attractive career option for nursing students. Knowledge deficit is a major perceived barrier to reliving ageist attitudes and behaviors among nursing students. In the Middle East, there is limited evidence regarding ageism among nursing students. This study aimed to examine the association of nursing students’ demographics and knowledge of aging with ageist attitudes and behaviors. A cross-sectional design was used to recruit a convenience sample of 290 undergraduate nursing students in Jordan. The majority of nursing students reported poor knowledge, held ageist attitudes, and expressed ageist behaviors. A significant difference was found between senior and junior nursing students in the level of knowledge about aging. Also, significant correlations were found among students’ knowledge about aging and ageist attitudes and behaviors. Targeting knowledge deficit and ageist attitudes and behaviors among nursing students is crucial for optimal geriatric care.RqkA, a DNA damage responsive serine/threonine kinase, is characterized for its role in DNA repair and cell division in D. radiodurans. Selleckchem IDN-6556 It has a unique combination of a kinase domain at N-terminus and a WD40 type domain at C-terminus joined through a linker. WD40 domain is comprised of eight β-propeller repeats held together via ‘tryptophan-docking motifs’ and forming a typical ‘velcro’ closure structure. RqkA mutants lacking the WD40 region (hereafter referred to as WD mutant) could not complement RqkA loss in γ radiation resistance in D. radiodurans and lacked γ radiation-mediated activation of kinase activity in vivo. WD mutants failed to phosphorylate its cognate substrate (e.g. DrRecA) in surrogate E. coli cells. Unlike wild-type enzyme, the kinase activity of its WD40 mutants was not stimulated by pyrroloquinoline quinine (PQQ) indicating the role of the WD motifs in PQQ interaction and stimulation of its kinase activity. Together, results highlighted the importance of the WD40 domain in the regulation of RqkA kinase signaling functions in vivo, and thus, the role of WD40 domain in the regulation of any STPK is first time demonstrated in bacteria. Communicated by Ramaswamy H. Sarma.COVID-19 is an exceptional public healthcare emergency that affected all countries. The corona virus pandemic has made the treatment of all cancers difficult. This international phenomenon represents an outbreak in medicine and this situation is a major issue for all patients, whether they are infected with the virus or not. Colorectal cancer is one of the most common malignant tumors of the digestive tract which needs special multidisciplinary care. Treatment modalities including chemotherapy and targeted therapies can weaken the immune system and then cause serious or lethal coronavirus infections. This document gives an idea about how we dealt to protect patients with colorectal cancer at Salah Azaiez Institute during COVID 19 pandemic.

Central diabetes insipidus is a heterogeneous condition characterized by decreased release of antidiuretic hormone by the neurohypophysis resulting in a urine concentration deficit with variable degrees of polyuria. The most common causes include idiopathic diabetes insipidus, tumors or infiltrative diseases, neurosurgery and trauma. Temozolomide is an oral DNA-alkylating agent capable of crossing the blood-brain barrier and used as chemotherapy primarily to treat glioblastoma and other brain cancers.

Two men (aged 38 and 54 years) suddenly developed polyuria and polydispsia approximately four weeks after the initiation of temozolomide for a glioblastoma. Plasma and urine parameters demonstrated the presence of a urinary concentration defect.

The clinical and laboratory abnormalities completely resolved with intranasal desmopressin therapy, allowing the continuation of temozolomide. The disorder did not relapse after cessation of temozolomide and desmopressin and relapsed in one patient after rechallenge with temozolomide.